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Spaciotemporal analysis of immune responses in virus infection and tumor in animal models.
Japan (IFMSA-Japan) - Shiga medical university, Shiga
Yasushi Itoh, Hirohito Ishigaki, Misako Nakayama
Type of Research Project
- Basic science
What is the background of the project?
• In severe influenza virus infection, cytokine responses are dysregulated in infected hosts, so called cytokine storm or hypercytokinemia. Therefore, not only inhibition of viral propagation but also suppression of inflammatory cytokine responses are thought to be critical in treatment of severe influenza virus infection. In this project as a basic research, we plan to reveal time course and origins of cytokine production in animal models. • Immune responses against cancer are impaired in hosts carrying tumors in various degrees. Therefore, removal of immunosuppression may enhance anti-cancer therapy. In this project, we plan to examine expression of various immunosuppressive molecules and cytokines in immune cells and tumor cells in different stages of tumor progression and after experimental treatments.
What is the aim of the project?
The aim of the research is to find molecular targets to control inflammatory responses and to develop compounds and devices for treatments. For this aim, we will reveal pathogenicity of influenza virus infection and tumors in this project.
What techniques and methods are used?
Immunohistochemical staining, fluorescence microscopy, flow cytometry
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
-Making and staining tissue sections. -Observation of tissue sections with a microscope and taking photos. -Staining of cells with antibody and analyzing them using a flow cytometer. -Culturing and staining of cells with antibody, observation and taking photos. -Culturing of cells and measurement of cytokines. -Making a brief report and presentation at lab meeting.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
At the beginning of the project, tutors will provide short lectures to explain purposes and background information of the project.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student’s name will be mentioned in a future publication - The student will prepare a presentation - The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Taking basic anatomy, histology and immunology courses is recommended. If the participant has experiences in making histological sections, observation of tissue sections under a microscopy, flow cytometry and basic molecular biology technique, they may help to study here but they are not necessary. The participant is expected to have experiences of pathological analysis, attend lab meetings, work together, ask many questions, discuss and enjoy science.
Are there any legal limitations in the student’s involvement
Since there are some intramural regulations on animal experiments and biosafety, the participant does not handle animals or live pathogens without permission. There is a security and trading regulation on accepting of summer students.
Type of students accepted
This project accepts: - Medical students
- http://www.shiga-med.ac.jp/~hqpatho2/en/ _ Itoh; Y. Pathology International; Volumn 66; pp. 132-141; 2016
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