Projects
Name
Possible anti-inflammatory andanalgesic activity of Dasyatisamericana venom
University
University of the City of Sao Paulo- UNICID
Domain
Immunology
Departement
University of Sao Paulo City, Faculty of Medicine. Rua Butanta, numero 285. Bairro Pinheiros
Head
Dra. Denise Ballester
Tutor
Dra. Patricia Brigatte
Languages
English, French, German
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No No No No No No No Yes Yes Yes No No
Type of Research Project
- Basic science
What is the background of the project?
Marine organisms comprise approximately one-half of the total global biodiversity; therefore, they offer an important source for novel compounds that has been classified as the largest reservoir of natural molecules to be evaluated for drug activity. The marine competitive environment demands the production of quite specific and potent active molecules by organisms. These organisms have been continuously screened for pharmacologically active substances and till date over 6500 marine natural products have been isolated.
What is the aim of the project?
The aim of the project is to characterize a possible therapeutic effect of the Dasyatisamericana venom. For these purpose experimental pain and inflammatory animal models will be performed to investigate the possible anti-inflammatory and analgesic effect of the venom. Also the project will characterize if Dasyatisamericana venom interferes with general activity of the animals. The aim of the project is to characterize a possible therapeutic effect of the Dasyatisamericana venom. Also we will verify if this venom interferes with the general activity of the animals of mice. The general activity refers with the locomotion and rearing activity of the animals. The project will provide the synergy and friendship between national and international students about animal science.
What techniques and methods are used?
The abdominal writhing test will be used and the measurement of writhing induced by intraperitoneal injection of acetic acid will be performed to investigate the possible antiinflammatory effect of Dayastis americana venom. To investigate if venom interferes with general activity of the mice it will be use the open field test.
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The abdominal writhing test will be used and the measurement of writhing induced by intraperitoneal injection of acetic acid will be performed to investigate the possible antiinflammatory effect of Dayastis americana venom. To investigate if venom interferes with general activity of the mice it will be use the open field test.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
1
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
No skills are required. None special previous knowledge is required. None legal limitation is found in the project development. A scientific report will be necessary after the exchange.One of the aim of the project is to train the foreign student through his participation of the part of experimental undergraduate scientific research of medical students of University of Sao Paulo City. The foreign student will accomplish (under supervision bytutor and undergraduate student.) our pain research group in experiments using abdominal writhing test and the open field test.He will observe, with our medical students, the writhing induced by intraperitoneal injection of acetic acid and the possible anti-inflammatory effect of Dayastisamericana venom. Also, he will accomplish, with the undergraduate student if venom interferes with general activity (locomotion and rearing) of the mice it will be use the open field test. All scientific knowledge will be required at University of Sao Paulo City. It is important to point out the venom that will be used for the research study will be provided by Butantan Institute. The mice will be provided by University of Sao Paulo City.
Are there any legal limitations in the student’s involvement
No
Hours
6
Type of students accepted
This project accepts:
- Medical students
- Graduated students (less than 6 months)
- Pre-Medical students from the American-British system
Articles
- Handbook of Laboratory Animal Science; 2nd Edition; Volume I and II.
- Guide for the Care and Use of Laboratory Animals
- Rajeshkumar et al. Antiproliferative activity of marine stingray Dasyatissephen venom on human cervical carcinoma cell line. Journal of Venomous Animals and Toxins including Tropical Diseases (2015)