Projects
Name
Investigation of markers of clinical responses to anti-PD1 treatment in cancer
University
Brazil (DENEM) - Pontificia Universidade Catolica do Rio Grande do Sul (PUC-RS), Porto Alegre-RS
Domain
Immunology
Departement
Institute of Biomedical Research, PUCRS
Head
Paulo Marcio Pitrez, MD PhD
Tutor
Cristina Bonorino, PhD
Languages
English , Portuguese, Spanish.
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
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Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Immunotherapy for cancer is today becoming the first line treatment for several types of cancer. The genetic and cellular alterations that define cancer provide the immune system with the means to generate T cell responses that recognize and eradicate cancer cells. However, elimination of cancer by T cells is only one step in the Cancer-Immunity Cycle, which manages the delicate balance between the recognition of nonself and the prevention of autoimmunity. Identification of cancer cell T cell inhibitory signals, including PD-L1, has prompted the development of a new class of cancer immunotherapy that specifically hinders immune effector inhibition, reinvigorating and potentially expanding preexisting anticancer immune responses.
What is the aim of the project?
What is the aim of the project? Analyze tumor infiltrating lymphocytes and blood lymphocytes from cancer patients treated with anti-PD1 monoclonal antibodies, participating in phase III clinical trials for different markers of response activation, before and after immunotherapy.
What techniques and methods are used?
What techniques and methods are used.Mention the steps/stages in this project? Cell isolation from biopsies before and after treatment; flow cytometry analysis of infiltrating and circulating lymphocytes; analysis of clinical outcomes; correlation of findings with clinical responses.
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
What techniques and methods are used.Mention the steps/stages in this project? Cell isolation from biopsies before and after treatment; flow cytometry analysis of infiltrating and circulating lymphocytes; analysis of clinical outcomes; correlation of findings with clinical responses.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
1
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Dedication; good interpersonal relationships; lab background is always good; good writing is a plus. Subjects passed: immunology.
Are there any legal limitations in the student’s involvement
No
Hours
6
Type of students accepted
This project accepts:
- Medical students
- Graduated students (less than 6 months)
- Pre-Medical students from the American-British system
Articles
- ntibody therapeutics in cancer.Sliwkowski MX; Mellman I.Science
- Oncology meets immunology: the cancer-immunity cycle.
- Cancer immunotherapy comes of age.Mellman I; Coukos G; Dranoff G.Nature.