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Tumoral microenvironment: Immunohistochemistry M1 and M2 macrophage and its relationship with prognostic and predictive factors.
Universidad Nacional de Tucuman
Service of Pathology.
Sonia Marcela Ortiz Mayor
Sonia Marcela Ortiz Mayor
Type of Research Project
- Basic science
What is the background of the project?
Studies linked to the process of carcinogenesis and tumor progression have focused for years on the neoplastic cell with genotypic and phenotypic characteristics. Lately, after the extraordinary progress in this field it arises in addition to understanding tumor biology called cancer microenvironment. This consists of a variety of cells can be malignant or not. Among non-malignant cells are stromal cells, cells and an inflammatory infiltrate neovascularization where macrophages represent a prominent population. This present in the microenvironment of inflammatory infiltrate neoplastic tissues, there is a simple inflammation. Evidence suggests that these cells act as mediators stimulating growth factors that favor the proliferation of cancer cells. That is why their presence in the tumor microenvironment represent based on this premise a factor of poor prognosis. Evaluate the distribution pattern of the two subtypes of macrophages in front of tumor infiltration of colorectal cancer and its relationship with prognostic and predictive factors. Immunohistochemical study. The same will be done with four markers CD68, CD163, iNOS, VEGFA
What is the aim of the project?
Evaluate the distribution pattern of the two subtypes of macrophages in front of tumor infiltration of colorectal cancer and its relationship with prognostic and predictive factors.
What techniques and methods are used?
Immunohistochemical study. The same will be done with four markers CD68, CD163, iNOS, VEGFA
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student perform a rotation through the various stages of processing biopsy material. Selection of samples for study, histological processing, immunohistochemistry, microscopic observation. Optionally it is offered to participate in the activities of teaching service.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The student must have passed pathology
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
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