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Medical Genomics and Precision Medicine with molecular studies of cancer cells
Universita degli Studi di Salerno
Laboratory of Molecular Medicine and Genomics Dept of Medicine, Surgery and Dentistry
Prof. Alessandro Weisz
Prof. Alessandro Weisz
Type of Research Project
- Basic science
What is the background of the project?
The Laboratory of Molecular Medicine and Genomics (LMMGe) is a research center located in the Baronissi campus of the University of Salerno. Its research and training activities are integrated with those of the Medical School of the university and are mainly focused on biomedicine and biotechnologies applied to modern Medicine. There are many different projects which are being carried out in the laboratory and they are all focused on understanding the structure and function of the human genome and of specific epigenomes in addition to their involvement in basic pathophysiological processes. Nowadays, with new technologies, it is possible to analyze genome activity under physiological and pathological conditions in order to gain a global picture of functional interactions between the environment and the genome.
What is the aim of the project?
The lab has many projects that are focused on cancer cells, the aim of the projects is studying the small non-coding RNAs in tumor cell biology, the nuclear receptor actions in breast cancer and the study of DNA methylation in cancer cells.
What techniques and methods are used?
Next generation sequencing, microarray analysis and other technologies for genomics studies, including Bioinformatics
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
- The student will take active part in the practical aspect of the project. The student will observe the practical experiments but will be highly involved in the analysis of the results. Host students will actively participate in all activities and will benefit from daily interactions with senior lab members - PhD students - doctors and biologists in residency and the Tutor himself. Students are expected to participate with enthusiasm and dedication. Students will observe experts in the field - in some cases they may be involved directly into using next generation sequencing - microarray analysis and other technologies for genomics studies - including Bioinformatics. In addition they will take part in lab meetings and seminars.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
No theoretical teaching provided
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Good to excellent background in molecular biology, biochemistry, chemistry and biology is needed Previous knowledge of the techniques which will be used (cell culture, isolation and analysis of DNA and RNA from cells and tissues, etc.) are welcome but not an essential prerequisite
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
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