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Psychobiology of Early Life Stress.
Brazil (DENEM) - Pontificia Universidade Catolica do Rio Grande do Sul (PUC-RS), Porto Alegre-RS
Pediatrics and Child Health Graduate Program
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
My lab is focused on revealing the complex nature and underlying mechanisms of some of the most common psychiatric disorders, which adversely affect a large portion of society and furthermore, on novel treatment strategies to combat these debilitating disorders. I have a background in early life stress (ELS) studies as well as an established expertise in developmental psychopathology and stress immunology.
What is the aim of the project?
My research is driven by a strong interest in understanding how early stressful environments interact with our genetic structure and in many cases act as a genetic predisposition to psychiatric disorders including addiction, depression and stress later in life. Part of my research efforts are dedicated to understanding the implications of people who have had atypical or adverse experiences during childhood/adolescence, such as exposure to drugs, neglectful, abusive relationships, or traumatic experiences. Understanding the underlying neurobiological pathways associated with how ELS can aberrantly affect the course of brain development, promote immune response and elicit long-lasting molecular modifications ultimately leading to increased risk of psychopathology later in life are the key questions that my lab and our research aims to address.
What techniques and methods are used?
In line with this, we are currently evaluating the impact of ELS on immunity and cognition within Substance-Related and Addictive Disorders. For that, will be used Molecular biology after the experiments, animal research about the project before and during, neuroimaging in women during the experiments.
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
n line with this, we are currently evaluating the impact of ELS on immunity and cognition within Substance-Related and Addictive Disorders. For that, will be used Molecular biology after the experiments, animal research about the project before and during, neuroimaging in women during the experiments.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system
- Crack cocaine addiction; early life stress and accelerated cellular aging among women. Levandowski ML1 ; Tractenberg SG1 ; de Azeredo LA1 ; De Nardi T1 ; Rovaris DL2 ; Bau CH2 ; Rizzo LB3 ; Maurya PK3 ; Brietzke E3 ; Tyrka AR4 ; Grassi-Oliveira R1 . Prog Neuropsychopharmacol Biol Psychiatry. 2016 Nov 3;71:83-9. doi: 10.1016/j.pnpbp.2016.06.009. Epub 2016 Jun 21
- Distinct behavioral and immunoendocrine parameters during crack cocaine abstinence in women reporting childhood abuse and neglect. Levandowski ML1 ; Viola TW2 ; Prado CH3 ; Wieck A3 ; Bauer ME3 ; Brietzke E4 ; Grassi-Oliveira R5 . Drug Alcohol Depend. 2016 Oct 1;167:140-8. doi: 10.1016/j.drugalcdep.2016.08.010. Epub 2016 Aug 11.
- An overview of maternal separation effects on behavioural outcomes in mice: Evidence from a four-stage methodological systematic review. Tractenberg SG1 ; Levandowski ML1 ; de Azeredo LA2 ; Orso R1 ; Roithmann LG1 ; Hoffmann ES1 ; Brenhouse H3 ; Grassi-Oliveira R4 . Neurosci Biobehav Rev. 2016 Sep;68:489-503. doi: 10.1016/j.neubiorev.2016.06.021. Epub 2016 Jun 18.
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