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Biological dosimetry in patients with iodine therapy
Paraguay (IFMSA Paraguay) - Universidad Catolica de Asuncion
Genetic Toxicology Laboratory, Faculty of Health Sciences - Facultad de Ciencias de la Salud, Universidad Catolica de Asuncion.
Dra. Deidamia Franco de Diana
Dra. Deidamia Franco, Jaime Segovia, Celeste Vega, Diana Castiglioni
English, Spanish, Portuguese, Italian
Type of Research Project
- Basic science
What is the background of the project?
Treatment of differentiated thyroid cancer (DTC) with radioactive iodine (131I) is a standard procedure for the ablation of remnant thyroid tissue following surgery and for the treatment of iodine-avid metastases. Usually, patients are treated with standard activities reflecting the physicians rating of the highest safe or adequate dosage rather than with an optimized treatment activity based on prior measurement of the patients individual biokinetics. The main disadvantage in using a fixed activity approach is the failure to consider the individuality of the patient. Therefore, the rationale for using a dosimetry-based approach is to replace the conventional fixed activity regimen by a modern setting, which allows the administered therapeutic activity to be increased while avoiding undesired side effects.
What is the aim of the project?
To acquire knowledge and skills in the development of bioassays proposed for the detection of DNA damage.
What techniques and methods are used?
In vivo bioassays: micronucleus assay and nuclear abnormalities in mucous cells, comet assay “single cell electrophoresis essay” in peripheral blood.
What is the role of the student?
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student will participate in research projects developed within a scientific initiation program. It is expected that the student can join the group of laboratory members, acquiring knowledge and contributing with their own knowledge to the research.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation - The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The student should have already studied subjects such as cell Biology and Genetics. Biosecurity knowledge to work at the Laboratory. There are no legal limitations to the student's involvement in the project. A conference call will be requested with the student prior to acceptance of his participation in this project.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system
- articles): Fadel A; Chebel G; Di Giorgio M; Taja M; Bubniak R; Deminge M et al. Contribution of the Biological Dosimetry for Treatment Decisions in Patients with Differentiated Thyroid Carcinoma (DTC) under Radioiodine-131 Therapy [Internet]. Foroiberam.org. 2016 [cited 15 September 2016]. Available from: http://www.foroiberam.org/documents/193375/199920/Contribution+of+the+biological+dosimetry+for+treatment+decisions+in+patients+with+differentiated+thyroid+carcinoma+DTC+under+radioiodine+131+therapy/62eb6c6e-1d89-4662-ada7-057c4874085e;jsessionid=1640A4E2EF89D090E4CF95C7DF6CB922?version=1.0
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