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Staphylococcus aureus colonization and infection
Germany (bvmd) - Ruprecht-Karls-Universitaet, Heidelberg
Department of Infectious Diseases, Medical Microbiology, University Hospital Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
Prof. Dr. med. Klaus Heeg
Dr. Dennis Nurjadi
Type of Research Project
- Basic science
What is the background of the project?
Project: Determinants of Staphylococcus aureus colonization and its clinical impact. Our research focuses on the role of host factors, especially the cellular and innate immunity in influencing the propensity of an individual to be colonized by S. aureus. 20- 30% of healthy individuals are colonized by S. aureus in the nose and this is the most important reservoir in the human body.
What is the aim of the project?
1. To investigate the role of innate immunity (e.g. antimicrobial peptides in the skin) in determining carriage. 2. To investigate the interaction of cellular/adaptive immunity with the innate immunity in nasal colonization 3. To study the impact of colonization, in terms of infection (skin and soft tissue infections) 4. Epidemiological and clinical research on S. aureus virulence and resistance (e.g. MRSA)
What techniques and methods are used?
We use cell cultures and in vitro infection models to investigate the Staphylococcus aureus colonization and infection. Further real time qPCR (real-time quantitative polymerase chain reaction), flow cytometry, basic microbiology (culture, DNA and RNA isolation), PCR and antibiotic susceptibility testing will be used in the project.
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic knowledge in laboratory work would be beneficial. A scientific report is not demanded, however documentation of results and experiments is obligatory. No legal limitations For the use of students considering participating in the project, further information can be found from the following articles: Skin and soft tissue infections in intercontinental travellers and the import of multi-resistant Staphylococcus aureus to Europe._ Clin Microbiol Infect. 2015 Jun,21(6):567.e1-10 Impaired beta-defensin expression in human skin links DEFB1 promoter polymorphisms with persistent Staphylococcus aureus nasal carriage. J Infect Dis. 2013 Feb 15, 207(4):666-74 Persistent nasal carriage of Staphylococcus aureus is associated with deficient induction of human beta-defensin 3 after sterile wounding of healthy skin in vivo. Infect Immun. 2011 Jul,79(7):2658-62
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
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