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Risk markers for Cardiovascular Disease according to the genetic ancestry of African descent communities of Ouro Preto, Minas Gerais.
Federal University of Ouro Preto- UFOP
Department of Medical Sciences, Molecular Pathophysiology Laboratory, Medical School, Federal University of OuroPreto, OuroPreto, Minas Gerais, Brazil
Marcio Antonio Moreira Galvao
George Luiz Lins Machado Coelho
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Studies in the adult population of Ouro Preto demonstrated that it has a high prevalence of cardiovascular risk factors. It is also observed that the population is markedly of African descent, according to previous studies of genetic ancestry conducted by our group in children. However, there has not yet been a study to determine genetic ancestry and relates it to the prevalence of chronic diseases and genetic markers of cardiovascular risk in the adult population of the district areas of Ouro Preto. Thus, a study is necessary to know ancestry patterns in the population in question and its possible association with cardiovascular risk factors, which may be contributing to the high prevalence of chronic diseases. This project is included in the doctorate of Aline Priscila Batista, MS, who will be co-supervisor of the exchange students.
What is the aim of the project?
To determine the association between markers of genetic ancestry and cardiovascular risk markers (classics and genetics) in the districts of Lavras Novas, Chapada and Santo Antonio do Salto, the city of Ouro Preto, whose population has afrodescendencia in historical roots. Genotyping techniques will be used using allele-specific probes using PCR system Real-time TaqMan (LifeTechnologies) after standardization.
What techniques and methods are used?
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
It is necessary that the student is familiar with such instruments in laboratory pipettes, 96-well PCR plates, glassware in general. It also highlights the importance of basic knowledge of molecular biology and Real Time PCR technique. It is also important to know the student concepts and types of epidemiological studies.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- Yusuf et al.Global Burden of Cardiovascular Diseases/Part II: Variations in Cardiovascular Disease by Specific Ethnic Groups and Geographic Regions and Prevention Strategies.
- Yusuf et al.; Global Burden of Cardiovascular Diseases/Part I: General Considerations; the Epidemiologic Transition; Risk Factors; and Impact of Urbanization.
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