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Definition of new therapeutic strategies based on exosomes
Universita degli Studi di Udine
Istituto di Anatomia Patologica, Azienda Ospedaliero Universitaria di Udine, Ple S. Maria della Misericordia 15, 33100 Udine (Italy)
Prof. Carla Di Loreto
Dr. Daniela Cesselli Dr. Antonio Paolo Beltrami
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
It was recently shown that tumor cells and microenvironmental cells communicate through the release of exosomes. These latter are membrane vesicles that originate from multivesicular bodies, are released into the extracellular space and in bodily fluids of many cell types and, through their content of biologically active molecules (for example proteins, mRNAs, miRNAs), act as a powerful intercellulare communication system. As mentioned above, we have shown that even in the human gliomas, GASC (Associated Glioma Stem Cells) support cancer by releasing exosomes. Our aim is to assess a possible therapeutic strategy, named exoscure, taking advantage of exosomes as vehicle system of oncosuppressive factors, eg. miRNA. We have already obtained the miRNA profile of exosomes produced by GASC and GSC of LGG and HGG and by a bioinformatic approach we are selecting miRNAs whose silencing / overexpression could play a oncosuppressive role.
What is the aim of the project?
1. To establish the exosomes component/content responsible for their tumor supporting function;
2. To detect new therapeutic strategies that use exosomes to transfer oncosuppressive factors (miRNA / antagomir) to cancer cells Cell culture of stem cells from human gliomas
What techniques and methods are used?
Isolation of exosomes Gene transfer In-vitro assays to evaluate growth kinetic, cell death, motility, anchorage-independent growth
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Student must be: 1. strongly committed to be involved in a research program including several basic-research activities and 2. able to work in a team.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- Bourkoula E; et al. Glioma-associated stem cells: a novel class of tumor-supporting cells able to predict prognosis of human low-grade gliomas. Stem Cells. 2014;32(5):1239-1253.
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