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Immunolocalisation of mechanoreceptors in urinary bladder wall of patients with benign prostatic hyperplasia
Slovenia (SloMSIC) - University of Ljubljana, Ljubljana
Institute of Cell Biology, Faculty of Medicine, University of Ljubljana Vrazov trg 2, SI-1000 Ljubljana, Slovenia
Prof. Peter Veranic
Prof. Rok Romih, PhD
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Benign prostatic hyperplasia (BPH) is a chronic disease that afects men with increasing incidence and prevalence with their age. BPH is the most common cause of lower urinary tract symptoms (LUTS), which include problems associated with storage of urine and voiding. In recent years it has been postulated that mechanosensory receptors (mechanoreceptors) in the urinary bladder wall may participate in LUTS. Members of transient receptor potential channels (TRP channels), which are non-selective ion channels, have machanosensitive properties, however, their tissue and cell distribution in the bladder wall of patients with BPH is largely obscured.
What is the aim of the project?
The aim of the project is to test different protocols and antibodies for the localisation of TRP channels in the urinary bladder wall of patients with BHP.
What techniques and methods are used?
Various immunohistochemical methods will be used.
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student will prepare biopsy samples - obtained by transurethral resection of the prostate - for microscopy. He/she will perform immunohistochemical labellings on frozen sections using an array of antibodies. The results will be analysed in fluorescence microscope. It is expected from the student to criticaly evaluate acquired micrographs.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic knowledge of light microscopy principles is required. Logbook is demanded to be filled out during the exchange.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Pre-Medical students from the American-British system
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