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Definition of new prognostic factors for the Low Grade Glioma (LGG)
Universita degli Studi di Udine
di Anatomia Patologica, Azienda Ospedaliero Universitaria di Udine, Ple S. Maria della Misericordia 15, 33100 Udine (Italy)
Prof. Carla Di Loreto
Dr. Daniela Cesselli Dr. Antonio Paolo Beltrami
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
We have previously shown that a prognostic score, based on glioma associated stem cells (GASC) isolated from patient gliomas, is an independent prognostic factor outperforming biomarkers considered "gold standard" for either overall survival or progression free survival, outperforming biomarkers considered "gold standard". More recently, using next generation sequencing techniques conducted by the Institute for Applied Genomics (IGA), we highlighted 81 genes and 15 miRNAs that distinguish GASC isolated from low-grade glioma (LGG) with a good prognosis from those characterized by a rapid anaplastic transformation. To facilitate the introduction of these new markers in the clinical routine, we intend to confirm the results obtained at the cellular level studying their expression at tissue levels, taking advantage of our large LGG case study (see above). Specifically, genes differentially expressed at the level of GASC will be assessed by qRT-PCR in the RNA extracted from tissues. Once validated, the putative prognostic biomarkers will also be validated at the protein level (immunohistochemistry).
What is the aim of the project?
To introduce new prognostic factors for the early identification of LGG patients at high risk of rapid anaplastic transformation.
What techniques and methods are used?
Immunohistochemistry Image-analysis Statistics
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Student must be: 1. strongly committed to be involved in a research program including several basic-research activities and 2. able to work in a team.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- Bourkoula E; et al. Glioma-associated stem cells: a novel class of tumor-supporting cells able to predict prognosis of human low-grade gliomas. Stem Cells. 2014;32(5):1239-1253.
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