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Neuroprotective effect of minocycline in diabetic retinopathy
Portugal (PorMSIC) - University of Coimbra, Coimbra
Retinal Dysfunction & Neuroinflammation Lab, Centre of Ophthalmology and Vision Sciences, IBILI
Antonio Francisco Ambrosio, PhD
Elisa Regina Figueiras Juli
Type of Research Project
- Basic science
What is the background of the project?
Diabetic retinopathy is the most common chronic diabetes mellitus eye disease and one leading cause of vision loss and blindness among adults worldwide. Diabetic retinopathy has long been recognized as a microvasculopathy, but retinal neuropathy, characterized by inner retinal neurodegeneration and neuroinflammation, also occurs in people with diabetes mellitus. Minocycline is a semi-synthetic tetracycline analog. Besides its bacteriostatic capacity, minocycline exerts anti-inflammatory, anti-apoptotic, and neuroprotective effects in several experimental models. We are investigating the neuroprotective effect of minocycline in retinal neuroinflammation, in diabetic retinopathy.
What is the aim of the project?
We aim to study the neuroprotective effect of minocycline in retinal neuroinflammation, using a type 1 diabetes animal model.
What techniques and methods are used?
We will evaluate the expression and distribution of several neuroinflammation markers by immunohistochemistry, in retinal slices.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student will perform the experimental part of this study, using the techniques above mentioned. During the training, the student will be able to interact with all the members of the lab, sharing his/her experiences and knowledge. We aim that the student improve his/her scientific, technical and personal skills.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Theoretical concepts will be provided to the student during the training.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Preferably, student must have basic experience and knowledge in Biology and/or Biochemistry. There are no legal limitations to the student's involvement in the project.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- Scholz R; et al. 2015. Minocycline counter-regulates pro-inflammatory microglia responses in the retina and protects from degeneration. J Neuroinflammation. 12:209. doi: 10.1186/s12974- 015-0431-4.
- Sun C; et al. 2013. Neuroprotective effect of minocycline in a rat model of branch retinal vein occlusion. Exp Eye Res. 113:105-16. doi: 10.1016/j.exer.2013.05.018.
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