Evaluation of neuropathological alterations induced by excitotoxic stimulation in mice
Federal University of Minas Gerais (UFMG)
Pharmacology Department, Instituto de Ciencias Biologicas, Universidade Fedearal de Minas Gerais, Av Pres. Antonio Carlos 6627, ZIP CODE 31270-901, Belo Horizonte, MG, Brasil.
Daniele Cristina de Aguiar
Antonio Carlos Pinheiro de Oliveira
English , Portuguese, Spanish.
4 weeks
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
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Type of Research Project
- Basic science
What is the background of the project?
Excitotoxicity is a biological process characterized by severe neuronal stimulation by glutamate. This over-stimulation by glutamate or other stimulation induces an excessive influx of calcium ions, triggering the activation of enzymes and cell death. This process is associated with certain diseases as stroke, traumatic brain injury, multiple sclerosis, Alzheimers disease, epilepsy, Parkinsons disease and Huntingtons disease. Excitotoxicity could induce functional deficits, such as impaired cognition and motor skills. However, its necessary to characterize different types of excitotoxic stimuli for use in preclinical research. The quinolinic acid (QA) is used as an excitotoxic stimulus activating NMDA-receptors and its administration in the striatum of animals is used to induce neuronal death. Little is known about the core end after peripheral administration of a drug. Thus, it is required characterization of the effect of systemic administration of QA on behavioral changes, as well as on the cell viability and activation of glial cells.
What is the aim of the project?
The objective of this project is to evaluate the effect of intraperitoneal administration of QA on memory, motor behavior, neuronal death and microglial activation.
What techniques and methods are used?
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Knowledge of basic Biochemistry, basic Physiology and basic Pharmacology.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts:
- Medical students
- Pre-Medical students from the American-British system
- Studies on the pathophysiology and genetic basis of migraine.
- The biology of the glutamatergic system and potential role in migraine
- Excitotoxicity: perspectives based on N-methyl-D-aspartate receptor subtypes.