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Current diagnostic application of immunohistochemical and molecular testing for human cancer
Japan (IFMSA-Japan) - University of Occupational & Environmental Health Medical, Fukuoka
Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan
Masanori Hisaoka, Kazuyoshi Uchihashi
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
The applicant(s) of the project would be involved in processing pathological materials as well as in conducting immunohistochemistry (IHC) and molecular testing in addition to attending inspection at pathological diagnosis of human cancers. Histopathological and molecular genetic features of a variety of rare cancers such as bone and soft tissue sarcomas can by reviewed by the applicant(s) under the guidance of the above tutors.The above department has solid background in pathologically diagnosing a wide variety of human cancers using multiple ancillary techniques (i.e. IHC and molecular testing) and in educating surgical pathologists and researchers including postgraduate students.
What is the aim of the project?
In order to better understand current diagnostic procedures of human cancers, the project would be planned.
What techniques and methods are used?
Standard histopathology, immunohistochemistry and molecular techniques (e.g. PCR, fluorescence in situ hybridization)
What is the role of the student?
- The student will mainly observe
What are the tasks expected to be accomplished by the student?
He/she would be expected to behave in an active or competitive manner as a provisional trainee in diagnostic pathology or a guest member of the department. Whether the applicant is involved in routine diagnostic practice and/or research projects would basically depend on his/her requests. The following techniques are available: microscopy, histochemistry, immunohistochemistry, polymerase chain reaction and cell culture. In case of hesitating participation, he/she can just observe our work.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Brief lectures or seminars would be provided, if necessary.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
At least standard knowledge of basic science and medicine including pathology is required. There are no legal limitations in the project, and no scientific report would be demanded after the exchange. Any exchange of knowledge or ideas with regard to clinical medicine including diagnostic pathology would be welcome.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- 1) Shibuya R; Matsuyama A; Nakamoto M; Shiba T; Hisaoka M. The combination of CD99 and NKX2.2; a transcriptional target of EWSR1-FLI1; is highly specific for the diagnosis of Ewing sarcoma. Virchows Arch 465(5):599-605; 2014.
- 2) Shibuya R; Matsuyama A; Shiba E; Harada H; Yabuki K; Hisaoka M. CAMTA1 is a useful immunohistochemical marker for diagnosing epithelioid haemangioendothelioma. Histopathology 67(12): 827-835; 2015.
- 3) Shiba E; Matsuyama A; Shibuya R; Yabuki K; Harada H; Nakamoto M; Kasai T; Hisaoka M. Immunohistochemical and molecular detection of the expression of FGF23 in phosphaturic mesenchymal tumors including the non-phosphaturic variant. Diagn Pathol 11(1): 26; 2016.
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