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The mechanism of metastasis and invasion of human cancer.
Department of Patholoigy Toho Univerisity School of Medicine, 5-21-16, Omori-Nishi, Ota-ku, Tokyo 143-8540, Japan
Type of Research Project
- Basic science
What is the background of the project?
Description: As a pathology department, we are investigating biological behavior of human cancer, using surgically resected materials, tumor cell lines, etc. Aim: Our lab is focused on the behavior of human cancer. For example, mechanism of invasion, mechanism of tumorigenesis from chronic inflammation, characteristics of cancer in association with molecular targeted drug, etc. Techniques: We use mainly histological examination; for example, immunohistochemistry, in situ hybridization, PCR of oncogenes using DNA extracted from histologic materials. Our materials include cancer tissue which was surgically resected and routinely processed, and cancer cell lines.
What is the aim of the project?
Our lab is focused on the behavior of human cancer. For example, mechanism of invasion, mechanism of tumorigenesis from chronic inflammation, characteristics of cancer in association with molecular targeted drug, etc.
What techniques and methods are used?
We use mainly histological examination; for example, immunohistochemistry , in situ hybridization, and some molecular pathological techniques. Our materials include cancer tissue surgically resected and routinely processed, cancer cell lines.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
It depends on the time schedule and request of the student. If possible, we expect the student to help partly our research. During the program, the student will be expected to learn how to design and perform the experiments of the research. Ideally, the findings that he/she obtains should be reported at an academic meeting or in a peer-reviewed scientific journal.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Before demonstration of each method, small lectures will be given to cover its theoretical basis and practical applications.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
At least, basic knowledge about histology of human tissue is required
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Pre-Medical students from the American-British system
- Tumor budding; myofibroblast proliferation; and fibrosis in obstructing colon carcinoma: the roles of Hsp47 and basic fibroblast growth factor. Xu CJ; Mikami T; Nakamura T; Tsuruta T; Nakada N; Yanagisawa N; Jiang SX; Okayasu I. Pathol Res Pract. 2013 Feb 15;209(2):69-74.
- Invasive behavior of ulcerative colitis-associated carcinoma is related to reduced expression of CD44 extracellular domain: comparison with sporadic colon carcinoma. Mikami T; Yoshida T; Numata Y; Kikuchi M; Araki K; Nakada N; Okayasu I. Diagn Pathol. 2011 Apr 7;6:30.
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