Projects
Name
Molecular Genetics and epigenetics in urothelial carcinomas such as prostate cancer and bladder cancer.
University
Greece (HelMSIC) - University of Thessaly, Larissa
Domain
Pathology
Departement
Department of Pathology, Faculty of Medicine, University of Thessaly, Biopolis, Larissa.
Head
Department of Pathology, Faculty of Medicine, University of Thessaly, Biopolis, Larissa.
Tutor
Samara Maria
Languages
English
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No No No No No Yes Yes No No No No No
Type of Research Project
- Basic science
What is the background of the project?
Nowadays there is a remarkable progress in the identification of common genetic aberrations in prostate cancer. Many genes and altered pathways are implicated. A single gene alteration in the pathway is enough to cause a pathway dysfunction. A significant point is that localized and treatment na
What is the aim of the project?
-
What techniques and methods are used?
-
What is the role of the student?
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
What are the tasks expected to be accomplished by the student?
Assist in the Lab Work of the project
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
1
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The student must be very careful with the material and has to act in accordance to the given instructions. Success in courses like Molecular Biology and Genetics is evaluated positively. No legal limitations.
Are there any legal limitations in the student’s involvement
No
Hours
6
Type of students accepted
This project accepts:
- Medical students
- Graduated students (less than 6 months)
Articles
- Baca SC; Prandi D; Lawrence MS; Mosquera JM; Romanel A; Drier Y; et al. Punctuated evolution of prostate cancer genomes. Cell 2013; 153: 666-77
- Taylor BS; Schultz N; Hieronymus H; Gopalan A; Xiao Y; Carver BS; et al. Integrative genomic profiling of human prostate cancer. Cancer Cell 2010; 18: 11-22.
- Grasso CS; Wu YM; Robinson DR; Cao X; Dhanasekaran SM; Khan AP; et al. The mutational landscape of lethal castration resistant prostate cancer. Nature 2012;487: 239-43
- Baylin SB; Jones PA. A decade of exploring the cancer epigenome - biological and translational implications. Nat Rev Cancer 2011; 11: 726-34.
- Chiam K; Ricciardelli C; Bianco-Miotto T. Epigenetic biomarkers in prostate cancer: Current and future uses. Cancer Lett 2014; 342: 248-56.
- Partin AW; Van Neste L; Klein EA; Marks LS; Gee JR; Troyer DA; et al. Clinical validation of an epigenetic assay to predict negative histopathological results in repeat prostate biopsies. J Urol 2014; 192: 1081-7.