Determinants of glycaemic control in type 1 diabetes in patients on continuous subcutaneous insulin infusion compared with multiple daily insulin injections
Serbia (IFMSA-Serbia) - University of Belgrade, Belgrade
Department for metabolic disorders, cell therapy, and intensive treatment in diabetes, Clinic for Endocrinology, diabetes and metabolic diseases, Clinical center of Serbia, Dr Subotica 13, Belgrade, Serbia
Professor Dr. Nebojsa M. Lalic
Prof. Dr. Nebojsa Lalic, Prof. Dr. Aleksandra Jotic, Ass. Dr. Ljiljana Lukic, Ass. Dr. Tanja Milicic
4 weeks
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
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Type of Research Project
- Clinical Project without Laboratory work
What is the background of the project?
Intensified insulin therapy with MDI (multiple daily insulin injections) or CSII (continuous subcutaneous insulin infusion) is well established as being of major importance for minimising the development of microvascular disease in type 1 diabetes. We investigate the factors that determine the best glycaemic control on MDI and CSII, and the hypothesis that blood glucose variability is a major determinant of control and that the resultant HbA1c on MDI correlates with the improvement achieved by CSII. The factors that influence the degree of control that is possible on MDI are unclear. Much of what is known about the barriers to strict glycaemic control relates to either hypoglycaemia or demographic and psycho-social factors such as age, motivation and compliance, diabetes education and coping skills. The improvement in glycaemic control on transfer to CSII is also variable, but recent trial in hypoglycaemia-prone subjects showed that the mean improvement in HbA1c on CSII.
What is the aim of the project?
The aim is to compare glycaemic control and insulin dosage as well as the rate of hypoglycemic episodes in people with type 1 diabetes treated by continuous subcutaneous insulin infusion compared with multipledaily insulin injections.
What techniques and methods are used?
Practical skills as physical examination and training of the patients with type 1 diabetes in terms of using the insulin pump, standard laboratory analysis, and statistical analysis.
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The role of the student is to help doctors with patient examination and education. This could be done in two ways: first, the student should make a quick evaluation of the patient and make an agreement with the staff about the approach, or speak directly to the patient (student will speak with patient if patient speaks English, and if not, the staff will translate the instructions to patients). The student would be there to help patients with using insulin pump for the first time. He/she will also take part in assessment if correction of the insulin dosage is needed (according to the protocol), with the aim of achieving a more optimal glycemic control in patient.Student will also collect data and make a database. If the student shows interest statistical analysis training will be provided.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster
- The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
It is preferred that the student passed the Internal medicine exam.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts:
- Medical students
- Graduated students (less than 6 months)
- 1. Task Force for Insulin Pump Management AACE/ACE Consensus Statement; Endocr Pratc 2014.; American diabetes association standards of medical care in diabetes?2015; NICE guidelines