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Modulation of bone function in vitro
Germany (BVMD) - Eberhard Karls Universitaet, Tuebingen
Siegfried Weller Institut fuer Unfallmedizinische Forschung Schnarrenbergstrasse 95 72072 Tuebingen
Prof. Dr. rer. nat. Andreas K. Nuessler
Dr. sc. hum. Sabrina Ehnert, firstname.lastname@example.org
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
We investigate primary human osteoblasts / osteogenic cell lines’ functions under defined conditions for a better understanding of osteogenesis / osteogenic mechanisms/mechanisms occurring during fracture healing and metabolic bone diseases. We are currently investigating the role of cigarette smoke extract on the proliferation and function of osteoblasts and trying to find the molecular signaling pathways involved in the process.
What is the aim of the project?
Development of new therapeutic strategies to improve osteoblast function; enable better bone remodeling events which could to translated to the clinical settings so as to help patients with fractures to heal better.
What techniques and methods are used?
Molecuar, biochemical and cell culture techniques; analytical software
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Participating in the project (osteoblast isolation, differentiation and culturing, RNA isolation, RT-PCR western blot analysis, AP assay, immunostaining etc), profiting from hands-on experience with various techniques, contributing to intercultural exchange, doing experimental evaluations, giving presentations of results, participating in discussion of results, participating in weekly lab meetings.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Basic subject background, weekly trainings and discussions, introduction into techniques
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation - The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic knowledge of medical and / or life science
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Pre-Medical students from the American-British system
- Vester H; Holzer N; Neumaier M; Lilianna S; Nüssler AK; Seeliger C: Green Tea Extract (GTE) improves differentiation in human osteoblasts during oxidative stress. J Inflamm (Lond). 2014;11: 15
- Haug AT; Braun KF; Ehnert S; Mayer L; Stöckle U; Nüssler AK; Pscherer S; Freude T: Gene expression changes in cancellous bone of type 2 diabetics: a biomolecular basis for diabetic bone disease. Langenbecks Arch Surg. 2014;399(5): 639-47
- Wang Z; Ehnert S; Ihle C; Schyschka L; Pscherer S; Nussler NC; Braun KF; Van Griensven M; Wang G; Burgkart R; Stöckle U; Gebhard F; Vester H; Nussler AK: Increased oxidative stress response in granulocytes from older patients with a hip fracture may account for slow regeneration. Oxid Med Cell Longev. 2014;2014: 819847
- Yan X; Ehnert S; Culmes M; Bachmann A; Seeliger C; Schyschka L; Wang Z; Rahmanian- Schwarz A; Stöckle U; De Sousa PA; Pelisek J; Nussler AK: 5-azacytidine improves the osteogenic differentiation potential of aged human adipose- derived mesenchymal stem cells by DNA demethylation. PLoS ONE. 2014;9(6): e90846
- Ehnert S; Freude T; Ihle C; Mayer L; Braun B; Graeser J; Flesch I; Stöckle U; Nussler AK; Pscherer S: Factors circulating in the blood of type 2 diabetes mellitus patients affect osteoblast maturation - description of a novel in vitro model. Exp Cell Res;332(2): 247-58
- Pscherer S; Sandmann GH; Ehnert S; Nussler AK; Stoeckle U; Freude T: Delayed Fracture Healing in Diabetics with Distal Radius Fractures Acta Chir Orthop Traumatol Cech;82(4): 268-273
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