Projects
Name
[Zacatecas] Evaluation of protein markers and their association with preeclampsia development
University
Universidad Autonoma de Zacatecas
Domain
Biochemistry
Departement
Molecular Medicine Laboratory
Head
Dr. Margarita De La Luz Mart
Tutor
DSc. Margarita de la Luz Mart
Languages
English, Spanish
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes No
Type of Research Project
- Basic science
What is the background of the project?
Description of the Project Preeclampsia (PE) is a pregnancy multisystem disorder that is characterized by hypertension and proteinuria that develops after the 20th gestational week (GW). As PE is the pregnancy disorder with the highest maternal and fetal mortality rates, the identification of novel predictive PE biomarkers is necessary. Risk factor for preeclampsia include: obesity, prior hypertension, older age and diabetes mellitus, some are very common. Preeclampsia affects 2-8% of pregnancies worldwide and the hypertensive disorders are one of the most causes of death due to pregnancy. Women who have had preeclampsia are at increased risk to heart diseases and stroker later in life.
What is the aim of the project?
To evaluate the maternal plasma, urine, serum profiles of multiple proteins to determine their usefulness for identifying patients at risk of developing the disease. in order to find a tool for early detection of high sensitivity and specificity.
What techniques and methods are used?
We performed a nested cohort case-control study in which the participants were drawn from a cohort of 588 pregnant women followed from the first trimester to delivery as part of a screening study for adverse pregnancy outcomes in local Hospitals, from Zacatecas
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
1
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
They should be covered the 60% of their credits and to have high level of responsibility. Their previous research incursion is desirable but not limiting. They must have basic skills in the use of data sheets (like excel). It is not required to report after to exchange.
Are there any legal limitations in the student’s involvement
No
Hours
6
Type of students accepted
This project accepts:
- Medical students
- Pre-Medical students from the American-British system
Articles
- Plasma cancer biomarker multiplex screening and the risk of subsequent preeclampsia. 2014. Margarita L. Martinez-Fierro; et al . (2014) doi: http://dx.- doi.org/10.1016/j.ijcard.2014.10.168 .International Journal of Cardiology. ISSN: 0167-5273. PMID: 25464412.
- Expression levels of seven candidate genes in human peripheral blood mononuclear cells and their association with preeclampsia. 2013.
- Martinez-Fierro ML; et al (2013) doi: 10.3109/10641955.2013.853777. Hypertension in Pregnancy. ISSN: 1064-1955. PMID: 24295154