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[Sonora] Effects of hyperglycemia in the neurovascular unit of the brain.
Mexico (IFMSA Mexico) - Universidad de Sonora, Sonora
Department of Medicine and Health Science, University of Sonora.
Dr. Norberto Sotelo Cruz
Marcelino Montiel Herrera
English, Spanish, Italian
Type of Research Project
- Basic science
What is the background of the project?
Description of the Project Cerebrovascular accidents are the second leading cause of death in the world and a major cause of disability in adults. This disease is characterized by a lack of blood flow in the neurovascular units of the brain. By using biomolecular tools, we are trying to understand how is modulated the expression of ion channels and membrane receptors in neurons, astrocytes and epithelial cells to uncouple the blood flow and supply of oxygen and glucose.
What is the aim of the project?
The aim of the project is to study the expression of ion channels and membrane receptors in neurons, astrocytes and epithelial cells during long periods of hyperglycemia in the rat brain.
What techniques and methods are used?
Ethically handle of animal models, brain slices, biomolecular tools (RT-PCR).
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic laboratory skills, and basic knowledge in chemistry, biochemistry. It is not required to report after to exchange.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system
- Stuart GJ et al. Pflugers Arch (1993) 423:511-518 (Brain slices)
- Montiel-Herrera et al. Glia (2006) 53: 366-71 (astrocyte cultures)
- Koide et al. 2012. Proc Natl Acad Sci U S A 109:E1387-1395 (biomolecular tools such as RT-PCR).
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