Interactions between a new drug delivery system based on gold nanoparticles and the cornea
Université Laval
Department of ophthalmology, Faculty of medicine, Universite Laval, 1050, avenue de la Medecine, Pavillon Ferdinand-Vandry, Bureau 4633, Ville de Quebec, QC G1V 0A6 CANADA
Yolande Dube
Elodie Boisselier
English or French
4 weeks
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
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Type of Research Project
- Basic science
What is the background of the project?
In Canada, more than 1.6 million people suffer from vision loss. Three diseases are involved in most cases of vision loss: age-related macular degeneration (AMD), glaucoma and cataracts. Ophthalmic drugs are topically administrated as drops in 90% of cases. However, only 10% of the active substances are absorbed under optimal conditions. The major limitation of most ophthalmic drugs is their limited penetrance in the eye.
What is the aim of the project?
The project aims to develop a new drug delivery system which will improve the efficiency of the medication used in ophthalmology. It is based on increasing the mucoadhesive properties of nanoparticles that are used as drug delivery systems. This new delivery system will thus improve the efficiency of these drugs and reduce their toxicity and cost.
What techniques and methods are used?
Gold nanoparticles will be synthesized (inorganic chemistry) and their size, charge and viscosity (dynamic light scattering, zeta potential and rheometry) will be determined in the presence of mucins which are the proteins found at the cornea surface.
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The student will realize a formation before beginning laboratory experiments: Workplace Hazardous Materials Information System (WHMIS).
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts:
- Medical students
- E. Boisselier; D. Astruc (2009) Gold nanoparticles in nanomedicine: preparations; imaging; diagnotics; therapies and toxicity; Chem. Soc. Rev.; 38: 1759-1782