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The mechanism of sexual dimorphism on stress responses
Taiwan (FMS-Taiwan) - Tzu Chi University, Hualien
Department of Physiology, Medical School
Chung-Chih Kuo Ph.D.
Zung Fan Yuan
English or Mandarin
Type of Research Project
- Basic science
What is the background of the project?
Stress responses, including sympathoadrenal and hypothalamic-pituitary-adrenal axis activation (HPA), exists sexual difference. Studies indicate that androgens significantly decrease stress-induced HPA axis activation. The medial preoptic nucleus (MPN) exhibiting sex dimorphic structure and function and expressing androgen receptor innervate the PVH, which controls HPA axis. So, the MPN may be the locus androgen acts on to regulate the HPA activity to stress. However, how androgens inhibit HPA response to stress is still ambiguous.
What is the aim of the project?
This is a one year project with the goal to confer that how androgens inhibit HPA activity through the MPN. We plan to clarify if the neuronal activity at MPN is controlled by stress. If it is positive, androgens may alter the MPN response to stress. By providing a functional anatomical framework we may explore the mechanism which androgen acts and the role of MPN on stress-activated HPA axis.
What techniques and methods are used?
The subject we use to execute the project is rat. The techniques we need include: handle skill, brain surgery, behavior observation, immunohistochemistry.
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The students will learn to run the experiment and analyze the result.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- Kalil B et al.; Role of sex steroids in progesterone and corticosterone response to acute restraint stress in rats: sex differences. Stress 16(4): 452-460; 2013
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