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Epigenetic mechanisms of gene regulation in breast cancer stem cells
Greece (HelMSIC) - University of Ioannina, Ioannina
Department of Medicine, School of Health Sciences
M.Paschopoulos, T. Fotsis
Prof. Angeliki Magklara
Type of Research Project
- Basic science
What is the background of the project?
Description: Epigenetic mechanisms, such as DNA methylation and histone modifications, regulate gene expression and play an important role in the development and progression of several types of cancer, including breast cancer. Since epigenetic changes are potentially reversible, much effort has been directed, in recent years, to finding novel therapies that could restore the normal epigenetic landscape. LSD1/KDM1A is a histone demethylase, found overexpressed in a variety of tumors. It has, also, been implicated in the maintenance of cancer stem cells, a tumor subpopulation that is thought to support tumor growth, metastasis and recurrence after therapy. Aim and techniques: Our goal is to characterize the LSD1-mediated oncogenic signaling pathways in breast can cer stem cells, in an effort to validate its use as a druggable target. The techniques and methods that will be used are: Cell culture, growing of mammospheres, RT-PCR , Western Blot, other molecular biology techniques.
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Molecular Biology Techniques
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
It is desirable that the student has worked in a lab before and possesses theoretical and practical knowledge of basic molecular biology techniques such as PCR, electrophoresis etc.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- Biochimica et Biophysica Acta 1829 (2013) 981?986
- Biochimica et Biophysica Acta 1840 (2014) 3494?3502
- Lancet Oncol 2012; 13: e43?48
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