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Induction of plastic changes in spinal motor pathways
Yukari Ohki, Prof., PhD
Yukari Ohki, Tsuyoshi Nakajima
Type of Research Project
- Basic science
What is the background of the project?
Description:Patients with spinal cord disorders generally suffer from motor and sensory symptoms. Conduction disturbance in the pyramidal tract is mainly thought to cause the motor symptoms. However, in animal experiments, it is suggested that spinal interneuronal systems could be used even for the recovery of digital movements. Aim:We are developing techniques to facilitate recovery of motor functions in spinal patients. For that purpose, we try to induce long-lasting potentiation in the indirect cortico-motoneuronal pathway in human subjects, mediated by spinal interneurons. Techniques:Electrophysiological techniques (e.g. EMG, EEG, TMS (transcranial magnetic stimulation)) Movement analyses
What is the aim of the project?
We are developing techniques to facilitate recovery of motor functions in spinal patients. For that purpose, we try to induce long-lasting potentiation in the indirect cortico- motoneuronal pathway in human subjects, mediated by spinal interneurons.
What techniques and methods are used?
Electrophysiological techniques (e.g. EMG, EEG, TMS (transcranial magnetic stimulation)) Movement analyses
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
Plan and perform experiments with normal human subjects and patients, together with tutors. Analyze experimental data.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Preliminary readings, seminars
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
No pre-acquired skill is necessary. But basic knowledge about nervous system is required. Check meeting abstracts in past meetings of Society for Neuroscience (SfN)
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields
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