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Comparison of atherosclerotic coronary arteries and internal mammary artery in terms of structural and pathological pattern in patients with coronary artery disease
Turkey (TurkMSIC) - Cumhuriyet University, Sivas
Department of Pathology Cumhuriyet University School of Medicine
Prof. Dr. Sahande Elagoz
Prof. Dr. Sahande Elagoz
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Atherosclerosis is a chronic inflammatory disease developing in response to injury in the vessel wall and is characterized by the ?infiltration of mononuclear lymphocytes into the intima?, ?migration and proliferation of vascular smooth muscle cells? and ?accumulation of extracellular matrix?. Inflammation is caused by interactions between genetic and environmental factors. A number of cardiovascular diseases, such as restenosis, aneurysm, and atherosclerosis, are caused by vascular remodeling associated with complex adaptive reactions of different cell populations. These reactions include growth of smooth muscle cells, proliferation of endothelial cells, and the inflammatory response of macrophages. MicroRNAs (miRNAs), a class of short RNAs, play key roles in these biological processes. The results obtained from the study will contribute to explain the role of epigenetic mechanisms in pathological basis of atherosclerotic process of coronary arteries. Also, the results obtained from this study will be an important source of data in the development process of atherosclerotic plaque formation preventing drugs which will be developed by using micro RNAs in the future. In the recent clinical studies, it was determined that internal mammary bypass grafts are closest to ideal grafts in coronary artery bypass surgery. In this study, tissue samples taken from atherosclerotic coronary arteries and internal mammary artery during coronary artery by-pass surgery will be used. Tissue samples are planned to be taken from 24 patients during coronary artery by-pass surgery. Vascular tissues which have atheroclerotic plaque structure, will be detected after pathological examination of tissue samples taken during surgery. Then, the micro-RNA expression levels between atherosclerotic coronary artery and non-atherosclerotic internal mammary artery will be compared. In this study, micro-RNA expression differences between atherosclerotic stenosis formed coronary artery and non-atherosclerotic (angiographically normal) internal mammary artery of same individual will be identified. Thus, the genes and pathways which are regulated by these micro RNAs will be determined.
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The student is expected to have basic histology and pathology knowledge. There are no legal limitations in the student
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- 1. http://www.sciencedirect.com/science/article/pii/S030441650900035X
- 2. http://www.discoverymedicine.com/Bi-Kui-Zhang/2015/02/epigenetics-in-atherosclerosis-a-clinical-perspective/
- 3. http://www.sciencedirect.com/science/article/pii/S0021915011006411
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