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Impact of miRNAs inhibitors on managing of radioiodide refractory in papillary thyroid carcinoma
Poland (IFMSA-Poland) - Medical University of Warsaw, Warszawa
Department of Genomic Medicine Medical University of Warsaw Banacha 1a St., block F 02-097 Warszawa, Poland
Prof. Krystian Jazdzewski, M.D. Ph.D.
Theory, research, fieldwork: Anna Wojcicka, Ph.D, Monika Kolanowska, Ph.D, Wojciech Gierlikowski M.D.
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
The common treatment proposed for patients suffered from papillary thyroid carcinoma PTC is thyroid ablation and consequently radioiodide I131 therapy. However, there is a group of patients refractory for radioiodide treatment. Since the alternative therapies such as chemotherapy or teleradiotherapy are limited, the survival time of refractory patients is short due to aggressiveness of cancer. Thus still new therapies are tested. Gene SLC5A8 encodes for protein which firstly was described as the iodide transporter anchored in the membrane of thyrocytes, is AIT (ang. Apical Iodide Transporter). Further studies pointed SLC5A8 as the tumor growth suppressor gene and proved its downregulation in tumors including PTC.
What is the aim of the project?
The aim of the project is to use specific inhibitors of chosen microRNAs in purpose to supress their regulatory role for SLC5A8 and to restore specific level of expression of gene SLC5A8 in thyroid tumor derived cells.
What techniques and methods are used?
Students will be involved in projects including functional studies in vitro Used methods enclose: transfections of cell lines, PCR, real-time PCR, cloning, sequencing
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Participation and self-development.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
We would like to recruit a student of the 2nd - 4th year of medicine. Student should have basics skills of laboratory work and basic knowledge on internal medicine: - knowledge of good laboratory practice - good pipetting skills - theoretical knowledge of molecular biology techniques such as: nucleic acids isolation, PCR, real time PCR, cloning, in vitro plasmids transition to cell lines, sequencing methods incl. next generation sequencing - knowledge of thyroid cancer molecular basis, especially Papillary Thyroid Carcinoma - radioiodide refractory thyroid carcinoma
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
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