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RETINAL GANGLION CELL NEUROPROTECTION IN A RAT MODEL OF GLAUCOMA.
Poland (IFMSA-Poland) - Medical University of Silesia, Katowice
DEPARTMENT OF PHYSIOLOGY, MEDICAL UNIVERSITY OF SILESIA, MEDYKOW 18, 40-752 KATOWICE, POLAND
Prof. JOANNA LEWIN-KOWALIK, Md, PhD
MARITA PIETRUCHA-DUTCZAK, PhD, HALINA JEDRZEJOWSKA-SZYPULA, PhD
Type of Research Project
- Basic science
What is the background of the project?
Glaucoma, a progressive optic neuropathy is thought to be the main cause of severe visual impairment or permanent loss of vision. This type of optic neuropathy is characterized by damage of retinal ganglion cells (RGCs) and their axons, initially locating at the optic disc where axons exit the eye. RGC death is most commonly a consequence of elevated intraocular pressure (IOP), but high IOP is not the only pathological factor. New therapies and potential novel therapeutic targets must be developed to achieve progress in the treatment of this insidious disease. This study try to indicate substances that could have protective effects on RGCs in the glaucoma model.
What is the aim of the project?
The search for neurotrophic substances which prolong the survival of injured RGCs in the glaucoma rat model.
What techniques and methods are used?
Microsurgery (transcardially perfusion, eye removal, processing of retina, microinjection (injection of Polybead Microspheres into the anterior chamber of the eye - preparation of experimental model of glaucoma; intravitreal injection) microscopy, immunohistochemistry
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Participation and self-development.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Work with the laboratory animals, microsurgical techniques, microscopy and tissue processing. Basic skills in laboratory work. For work with animals, a certificate of animal care orientation would be appreciate (not obligatory)
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- Pietrucha-Dutczak et.al.Neural. Res. 2008; vol. 30; No 8; p. 845-851
- Smedowski; Pietruucha-Dutczak et al. Scientific Reports 2014; doi:10.1038/srep05910
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