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Bone cell dysfunction in inflammatory bone degenerative disease and endothelial cell dysfunction in vascular/valve calcification
Korea (KMSA) - Ulsan university, Seoul
Biotechnologies and Informatics
Department of Biomedical Sciences
Min-Sun Kim, MD.Ph.D
Eun-Ju Chang, Ph.D
Type of Research Project
- Basic science
What is the background of the project?
The bone microenvironment provides a fertile soil for cancer cells as well as a specialized cell niche for bone cells and supports the function of bone cells to maintain bone microarchitecture. It is beleived that reciprocal interactions between tumor cells and bone cells, known as the vicious cycle of bone metastasis contribute to the extablishment and orchestrate the expansion of malignant cancers in bone. Given the link between disturbed bone metabolism and vascular/valve calcification accounting for bone-vascular paradox, it is therefore not suprising that bone disease and vascular calcification are linked by common physiological control mechanisms.
What is the aim of the project?
The aims of our projects are to investigate the molecular and cellular mechanisms of: i. Cancer cell dysfunction in bone metastasis ii. Bone cell dysfunction in inflammatory bone degenerative disease (e.g., osteoporosis, rheumatoid arthritis and ankylosing spondylitis) iii. Endothelial cell dysfunction in vascular/valve calcification. These studies will provide novel therapeutic targets for treating various diseases associated with dysfunctional osteogenesis and osteolysis.
What techniques and methods are used?
i. Cellular and Molecular Biology Tools (i.e., cell culture, western blot, PCR, ELISA, cloning, etc.) ii. Immunological Analysis (i.e., FACS, confocal microscoly, etc.) iii. Establishment or Assessment of Animal disease Models
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The role of the student during participation is to involve our projects by performing experiments actively or as an assistant and that may contribute to publish papers as one of coauthors.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
There will be preliminary readings and seminars regarding the current project.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
No special skills are required.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system
- Dipeptidyl Peptidase-4 Induces Aortic Valve Calcification by Inhibiting Insulin-Like Growth Factor-1 Signaling in Valvular Interstitial Cells. Circulation. 2017 May 16;135(20):1935-1950.
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