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Sleep modulation and its effects on health and neurological disorders
Serbia (IFMSA-Serbia) - University of Belgrade, Belgrade
Laboratory of Neurophysiology, Institute of Medical Physiology "Richard Burian", Belgrade University Faculty of Medicine, Belgrade, Serbia, Visegradska 26/II 11000 Belgrade, Serbia
Prof. Dr. Olivera Stanojlovic, MD, PhD
Assist. Prof. Dr. Dragan Hrncic, MD, PhD, Assist. Prof. Dr. Aleksandra Rasic Markovic, MD, PhD, Prof. Dr. Olivera Stanojlovic, MD, PhD, dr Nikola Šutulović
Type of Research Project
- Basic science
What is the background of the project?
Sleep is a vital, natural, periodic and reversible physiological state of decreased vigilance. We are spending more than third of our lifes sleeping. Therefore, changes in sleep duration and architecture are associated with different diseases, from cardiovascular to variety of neurological and psychiatric disorders. Sleep disruption occurs in patients with different psychiatric and respiratory diseases, in particular in patients with sleep apnea. On the other hand, a number of neurological disorders are accompanied by sleep disorders. We still lack a lot of knowledge on the bidirectional relationship between sleep and neurological and psychiatric disorders.
What is the aim of the project?
The aim of the Project is to determine the mechanisms of the relationship between sleep modulation (deprivation and fragmentation) and anxiety and depressive-like behavior in the rodents.
What techniques and methods are used?
This study includes variety of common neurophysiologic methods and techniques. Particularly, the study will be based on techniques for REM sleep deprivation, sleep fragmentation using treadmill method, assessment of depressive-like behavior in rodents via forced swimming test, assessment of anxiety -related behavior in rodents via open field test, elevated plus maze and light - dark test. Bioelectrical brain activity will be analyzed by EEG recordings. Biochemical analysis in tissue samples will be used also.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Accepted students will be involved in regular laboratory team-building meetings, M&T discussions, in-ward journal clubs and national scientific meetings if available during their stay. Selected students will be a part of the research team and be in charge for certain responsibilities depending on their abilities, previous experience and attitudes. They will be directly included in performance of certain techniques and methods and responsible for part of the experimental work, including recorded behavioral data analysis, EEG signal analysis, etc. Wide range of common neurophysiology methods and techniques will be on disposal for work on. Particularly, students will have chance to gain skills on computerized video behavioral monitoring, assessing depression and anxiety in laboratory animals by standard tests, methods for sleep modulation (deprivation and fragmentation), as well as to develop their scientific writing skills and application of statistical analysis.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Theoretical introduction will be provide. Introductury leacture as well as disscussions on the topic will be arranged. Theoretical background of each method used will be clearly presented. Students are intended to participate in inward Lab journal clubs.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a presentation - The student will prepare a scientific report - The student will prepare an abstract - No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Manual dexterity is welcome. Basic knowledge of neurophysiology and pharmacology are needed.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields
- Hrncic D; Grubac Z; Rasic-Markovic A; Sutulovic N; Susic V; Bjekic-Macut J; Stanojlovic O. Sleep disruption increases seizure susceptibility: Behavioral and EEG evaluation of an experimental model of sleep apnea. Physiology and Behavior 2016;155:188-194. doi: 10.1016/j.physbeh.2015.12.016.
- Hrncic D; Rasic-Markovic A; Lekovic J; Colovic M; Krstic D; Macut D; Susic V; Djuric D; Stanojlovic O. Exercise decreases susceptibility to homocysteine seizures: the role of oxidative stress. International Journal of Sports Medicine 2014; 35(7):544-50
- Hrncic D; Rasic-Markovic A; Macut-Bjekic J; Susic V; Djuric D; Stanojlovic O. Paradoxical sleep deprivation potentiates epilepsy induced by homocysteine thiolactone in rats. Experimental Biology and Medicine 2013;238(1)77-83
- Stanojlovic O; Rasic?Markovic A; Hrncic D; Susic V; Macut Dj; Radosavljevic T; Djuric D. Two types of seizures in homocysteine thiolactone ? treated adult rats; behavioral and encephalographic study. Cellular and Molecular Neurobiology 2009; 29:329-39
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