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Experimental models of epilepsies: mechanisms and treatments
Serbia (IFMSA-Serbia) - University of Belgrade, Belgrade
Laboratory of Neurophysiology, Institute of Medical Physiology "Richard Burian", Belgrade University Faculty of Medicine, Belgrade, Serbia, Visegradska 26/II 11000 Belgrade, Serbia
Prof. Dr. Olivera Stanojlovic, MD, PhD
Prof. Dr. Olivera Stanojlovic, MD, PhD, Assist. Prof. Dr. Dragan Hrncic, MD, PhD, Assist. Prof. Dr. Aleksandra Rasic Markovic, MD, PhD
Type of Research Project
- Basic science
What is the background of the project?
Epilepsy is one of the major neurological disorders with prevalence of 1-2% and 30% of patients are refractory to available therapy. Experimental models of epilepsies are valuable for investigations of its mechanisms and therapy. Numerous mechanisms are involved in epileptogenesis, including overstimulation of NMDA receptors, changes in GABA transmission and signal processing mediated via NO, H2S and CO. Many of the new concepts in epileptogenesis are potential targets for development of further therapies. Moreover, epilepsy is accompanied by variety of psychiatric comorbidities, like anxiety and depression.
What is the aim of the project?
The aim of the Project is to develop experimental models of epilepsies that will serve for shedding more lights on the mechanisms of epileptogenesis and testing of potential antiepileptic drugs with implications on postictal comorbidities.
What techniques and methods are used?
This study includes variety of common neurophysiologic methods and techniques. Particularly, the study will be based on EEG registration and advanced-level signal processing, behavioral convulsive assessment, assessment of anxiety- and depressive-like behaviors in rodents via open field test, elevated plus maze and light - dark test and forced swimming test. Biochemical analysis in tissue samples will be used also.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Accepted students will be involved in regular laboratory team-building meetings, M&T discussions, in-ward journal clubs and national scientific meetings if available during their stay. Selected students will be a part of the research team and be in charge for certain responsibilities depending on their abilities, previous experience and attitudes. They will be directly included in performance of certain techniques and methods and responsible for part of the experimental work, including recorded behavioral data analysis, EEG signal analysis, etc. Wide range of common neurophysiology methods and techniques will be on disposal for work on. Particularly, students will have chance to gain skills on EEG recording procedure and method of biosignal processing, computerized video behavioral monitoring for assessing depression and anxiety in laboratory animals, treadmill methods for physical exercise of rodents, as well as to develop their scientific writing skills and application of statistical analysis.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Theoretical introduction will be provide. Introductury leacture as well as disscussions on the topic will be arranged. Theoretical background of each method used will be clearly presented. Students are intended to participate in inward Lab journal clubs.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a presentation - The student will prepare a scientific report - The student will prepare an abstract - No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Manual dexterity is welcome. Basic knowledge of neurophysiology and pharmacology are needed.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields
- Hrncic D; Rasic-Markovic A; Lekovic J; Colovic M; Krstic D; Macut D; Susic V; Djuric D; Stanojlovic O. Exercise decreases susceptibility to homocysteine seizures: the role of oxidative stress. International Journal of Sports Medicine 2014; 35(7):544-50
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