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Gene- and Cell-Therapies for Rare Hematological Diseases
Germany (bvmd) - Medizinische Hochschule Hannover, Hannover
Institute of Experimental Hematology REBIRTH Cluster of Excellence Medizinische Hochschule Hannover Carl-Neuberg-Strasse 1 30625 Hannover
Prof. Dr. Axel Schambach
Dr. Nico Lachmann (
Type of Research Project
- Basic science
What is the background of the project?
Our lab is interested in the evaluation of innovative cell replacement therapies using either multipotent- or pluripotent stem cell (PSC) derived hematopoietic cells. We gain insights in the process of human hematopoietic development from PSC and investigate PSC-derived myeloid cells in infectious diseases and rare hematopoietic disorders such as Pulmonary Alveolar Proteinosis (PAP), Mendelian Susceptibility to Mycobacterial Disease (MSMD) or very-early onset of Inflammatory Bowel Disease (veo-IBD).
What is the aim of the project?
The aim of this project is to gain knowledge about research in the hematopoietic system. Moreover, the student will gain insights in new techniques and going to improve his scientific thinking.
What techniques and methods are used?
The student will learn culturing of cells (cell lines), gain insights in hematopoietic differentiation of multipotent- and pluripotent-stem cells, cloning of constructs used for gene therapy applications and molecular biology work such as western-blot, RNA- and DNA-isolation as well as mini- and maxipreps.
What is the role of the student?
What are the tasks expected to be accomplished by the student?
The student will be enrolled in daily scientific activities and will perform on hands experiments to learn cutting edge research in the field of hematology. Therefore, high motivation and enthusiasm for science is a prerequisite to join our lab. Active discussions/contributions by the applicant and current labmembers will be expected.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
The student will get detailed introduction weekly into the field by personal meetings as well as lab-meeting and journal clubs
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Biosafety risk level 2 work may be included, therefore vaccination and health status report is requested - Excellent English skills proved by an international recognized language certificate such as TOEFL, Cambridge English Exam, IELTS are required - Knowledge or interest in hematology is beneficial - high motivation and enthusiasm for science is a prerequisite to join our lab; active discussions/contributions by the applicant and current labmembers will be expected Special remarks: As mentioned above, high motivation as well as English skills are required for this project. On the other hand, supervision, overall introduction and on hand experience into the field will be provided.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Students in biomedical fields
- Ackermann et al. 2015 EMBO Mol Med; Lachmann et al. 2015 Stem Cell Reports
- Suzuki et al. 2014 Nature; Happle et al. 2014 Science Trans Med; Lachmann et al.
- 2015 Am J Respir Crit Care Med
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