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Oxidative stress and childhood obesity: correlation between salivary and serum oxidized LDL levels
Universita degli Studi di Pavia
Department of Public Health, Experimental and Forensic Medicine ? Unit of Human Nutrition
Professor Carla Roggi
Hellas Cena, Rachele De Giuseppe
Type of Research Project
- Clinical Project without Laboratory work
What is the background of the project?
Among European countries, Italy has the highest rate of childhood obesity with a prevalence of overweight and obesity of 20.9% and 9.8%, respectively. Central obesity increases cardiovascular risk by means of classical (dyslipidemia, hypertension, glucose dysmetabolism) and less conventional mechanisms, such as oxidative stress. Oxidized LDL cholesterol (oxLDL) is a product of oxidative modification of low-density lipoprotein and plays an important role in the atheromatous plaque formation. Extreme pediatric obesity, compared to milder forms of adiposity and normal weight, was associated with higher levels of oxLDL. Salivary samples are non-invasive, safe, and easier to handle than serum. Recently, a significant correlation between salivary oxLDL levels and their counterpart in serum was observed in adult subject affected by overweight/obesity.
What is the aim of the project?
The study aims: i) To compare salivary and serum oxLDL levels between pediatric subjects affected by overweight/obesity and normal weight; ii)To verify possible correlation between salivary and serum oxLDL levels; iii) To verify possible correlation between salivary/serum oxLDL levels and biochemical-auxologic parameters in pediatric subjects affected by overweight/obesity; iv) To investigate salivary/serum oxLDL cut-off levels, both in pediatric subjects affected by overweight/obesity and in normal weight pediatric subjects.
What techniques and methods are used?
One-hundred subjects affected by overweight/obesity will be enrolled, according to inclusion criteria (age>8 years; overweight/obesity condition, according to Cole Index; absence of autoimmune diseases, cancer, secondary obesity, eating disorders, periodontitis). One-hundred healthy, normal weight, well matched for sex and age subjects, will be enrolled as controls. For each subject medical history, dietary habits (by using a previously validated questionnaire), auxologic (weight, height, waist circumference, body composition) and biochemical parameters (lipid panel parameters, glucose, insulin, C Reactive Protein, oxLDL levels) will be investigated. Serum and saliva oxLDL levels will be measured by a commercial enzyme-linked immunosorbent assay (Mercodia, Uppsala, Sweden).
What is the role of the student?
- The student will mainly observe
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Good knowledge of Physiology, Biochemistry and basics of Nutrition and Pathology.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
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- Ahrens W et al. Int J Obes (Lond) 2014
- web link: www.epicentro.iss.it/okkioallasalute/
- Van Gaal LF et al. Nature 2006
- Heinecke JW. Curr Opin Lipidol 1997
- Norris AL et al. Obesity (Silver Spring) 2011
- De Giuseppe R et al. Journal of Oral pathology & Medicine 2015.
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