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[Sonora] Chemico-structural, molecular, and biological study of chemopreventive compounds isolated from marine organisms.
Mexico (IFMSA Mexico) - Universidad de Sonora, Sonora
Department of Research and Graduate Studies in Food Science
Dr. Francisco Javier Wong Corral
Dr. Armando Burgos Hernandez
English and Spanish
Type of Research Project
- Basic science
What is the background of the project?
Cancer is one of the main causes of death worldwide. Primary prevention is possibly the best strategy to reduce cancer mortality rates. The chemoprotective properties of the compounds present in a wide variety of foods such as fruits, vegetable oils, seafood, among others, have extensively been reported. Seafood products are a rich source of bioactive molecules which are compounds that have been synthesized in extreme conditions that are very different from those proper of land organisms, which also makes them unique regarding to diversity, chemical structure and functional characteristics. A great variety of bioactive compounds have been reported from several marine sources, showing different kinds of biological activities, which makes them suitable to be proposed as potential chemotherapeutical agents.
What is the aim of the project?
The aim of the present research project is to isolate chempreventive compounds from octopus (Paraoctopus limaculatus) and shrimp (Litopenaeus vannamei) and evaluate their antimutagenic and antiproliferative activities in vitro and in vivo.
What techniques and methods are used?
Solvent partitioning extraction and fractionantion of marine organisms, fractionation and purification using open-column and high performance liquid chromatography, Ames test (bacterial/microsomal assay), Comet assay (DNA oxidative damage assay), cell-culture citotoxicity assay, NMR, mass spectrometry, in vivo studies with rodents.
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Written report for the end of the exchange
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic laboratory skills, and basic knowledge in chemistry, biochemistry.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- Susana-Gabriela Cruz-Ramirez; Maribel Plascencia-Jatomea; Enrique Marquez-Rios; Lorena Machi-Lara; Fernando Rocha-Alonzo; Carmen-Maria Lopez-Saiz; Armando Burgos-Hernandez*. Isolation and Identification of an Antimutagenic Phthalate Derivative Compound from Octopus (Paraoctopus limaculatus). Tropical Journal of Pharmaceutical Research; 14 (7): 1257-126
- Carmen-Maria Lopez-Saiz; Carlos Velazquez; Javier Hernandez; Francisco-Javier Cinco-Moroyoqui; Maribel Plascencia-Jatomea; Maribel Robles-Sanchez; Lorena Machi-Lara; Armando Burgos-Hernandez*. 2014. Isolation and Structural Elucidation of Antiproliferative Compounds of Lipidic Fractions from White Shrimp Muscle (Litopenneus vannamei). International Journal of Molecular Sciences. 15; 23555-23570
- Carmen-Maria Lopez-Saiz; Miroslava-Guadalupe Suarez-Jimenez; Maribel Plascencia-Jatomea; and Armando Burgos-Hernandez*. 2013. Lipids of shrimp: A source of chemopreventive compounds. Marine Drugs. 11: 3926-3950
- Carolina Moreno-Felix; Griselda Wilson-Sanchez; Susana-Gabriela Cruz-Ramirez; C. Velazquez; Maribel Plascencia-Jatomea; Ana L. Acosta; Lorena Machi-Lara; Maria-Lourdes Aldana-Madrid; Josafat-Marina Ezquerra-Brauer; Fernando Rocha-Alonzo; and A. Burgos-Hernandez*. 2013. Bioactive Lipidic Extracts from Octopus (Paraoctopus limaculatus): Antimutagenicity and Antiproliferative Studies. Evidence-based Complementary and Alternative Medicine; Volume 2013; Article ID 273582; 12 pages
- G. Wilson-Sanchez; C. Moreno-Felix; C. Velazquez; A. Acosta; L. Machi-Lara; M. L. Aldana-Madrid; J. M. Ezquerra-Brauer; R. Robles-Zepeda and A. Burgos-Hernandez* 2010. Antimutagenicity and Antiproliferative Studies of Lipidic Extracts from white shrimp (Litopenaeus vannamei). Marine Drugs; 8:2795-2809
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