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Modulation of neuronal communication
Portugal (PorMSIC) - University of Lisbon, Lisbon
Institute of Pharmacology and Neurosciences, Faculty of Medicine
Ana M Sebastiao
Sandra Vaz and Sara Xapelli
English, Portuguese, Spanish
Type of Research Project
- Basic science
What is the background of the project?
The basic principles of synaptic communication are well known but the fine ways excitatory and inhibitory synapses are finely tuned by locally released substances is yet poorly understood and the focus of the Unit work. As endogenous neuromodulators we have been focusing on adenosine, endocannabinoids and brain derived neurotrophic factor (BDNF). We are focusing on to cross-regulation by these endogenous neuromodulatory molecules at the hippocampus, having as working hypothesis that disruption of one signaling pathway may lead to changes in the homeostasis carried out by another pathway either at the membrane and/or at the intracellular level.
What is the aim of the project?
To understand how synaptic signaling is finely tuned by endogenous substances
What techniques and methods are used?
Electrophysiological recordings of synaptic potentials; calcium signaling in astrocytes; preparation of hippocampal slices and cell cultures; immunofluorescent labeling
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The students will closely interact with PhD Students and Post-docs in the Unit, following their experimental work, including the daily experiments( such as Electrophysiological recordings of synaptic potentials; calcium signaling in astrocytes; preparation of hippocampal slices and cell cultures; immunofluorescent labeling) , data analysis, elaboration of protocols. It is expected that the students will perceive, by vivid experience, the everyday life of a research unit.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
To discuss and interpret scientific data
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- Neuromodulation and metamodulation by adenosine: Impact and subtleties upon synaptic plasticity regulation. Ana M. Sebastia on ; Joaquim A. Ribeiro Instituto de Farmacologia e Neurociências; Faculdade de Medicina e Unidade de Neurociências; Instituto de Medicina Molecular; Universidade de Lisboa; Lisboa; Portugal
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