Projects
Name
Molecular signatures of chemoresistance in human ovarian cancers
University
China (IFMSA-China) - Fudan University, Shanghai
Domain
Biology
Departement
Center Laboratory, Jinshan Laboratory
Head
Guoxiong Xu, M.D., Ph.D.
Tutor
Guoxiong Xu, M.D., Ph.D.
Languages
English, Chinese
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No No No No No No Yes Yes No No No No
Type of Research Project
- Basic science
What is the background of the project?
Human epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy and constitutes over 90% of the cases of ovarian cancer. Taxol and platinum are the first-line anti-EOC drugs in conjunction with cytoreductive surgery. Although the response rate in the initial chemotherapy is about 70-80%, most EOC patients experience recurrence and resistance to chemotherapy. The chemoresistance results in part from our incomplete understanding of the mechanisms of chemoresistant development. _The aim is to explore the molecular signature of RNAs and proteins associated with chemoresistance in ovarian cancer cells. Quantitative RT-PCR, Western blot and/or immunohistochemistry will be used for the detection of RNAs and proteins
What is the aim of the project?
The aim is to explore the molecular signature of RNAs and proteins associated with chemoresistance in ovarian cancer cells.
What techniques and methods are used?
Quantitative RT-PCR, Western blot and/or immunohistochemistry will be used for the detection of RNAs and proteins.
What is the role of the student?
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student(s) will learn the basic skills of lab methods such as RT-PCR and Western blot to investigate the RNAs and proteins. She/he will acquire the knowledge of Oncology and Molecular Biology.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Yes. Student(s) will attend seminar, lab meeting, journal club etc.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
There is no special skill required for the enrollment. Any students interested in molecular biology of cancer are welcome. There is no legal limitation in the project. For the use of students considering participating in the project, further information can be found from the following articles (please add specific articles): Tian X, Xu G. Clinical value of lncRNA MALAT1 as a prognostic marker in human cancer: systematic review and meta-analysis. BMJ Open 2015 Sep 30;5(9):e008653. _ Wang X, Gui L, Zhang Y, Zhang J, Shi J, Xu G. Cystatin B is a progression marker of human epithelial ovarian tumor mediated by the TGF-
Are there any legal limitations in the student’s involvement
No
Hours
8
Type of students accepted
This project accepts:
- Medical students
- Graduated students (less than 6 months)
- Pre-Medical students from the American-British system
Articles