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Epigenetic changes in burnout syndrome
Belgium (BeMSA) - KU Leuven, Leuven
Global Health and Neglected Diseases
Environment and Health
Prof. Godderis, Bakusic Jelena
English, Dutch, French
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Our lab investigates the impact of work on health by unraveling the underlying mechanisms. At the same time our lab investigates the impact of disease on ability to work. Burn-out is a common problem in our society, not much is known about the effect of burn-out and the cause of burn-out. Research shows that about 22% of the working people have a high risk of burnout and that the number of sick day rises with 8 days per person (article by IDEWE (Non-Governmental Organisation for safety in the work environment) 2011). Compared to other sectors, burnout is more prevalent in caregivers, such as doctors and nurses (Prins, 2010). Research of Vu (2009) revealed that 1 out of 3 Intensive Care Unit (ICU) doctors struggles with burnout.
What is the aim of the project?
To study the effect of particles on the genome and epigenetic changes.
What techniques and methods are used?
Liquid chromatography–mass spectrometry (LCMS), High- performance liquid chromatography (HPLC), pyro sequencing, essay will be used for analysis of the samples
What is the role of the student?
- The tasks will be done under supervision
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
The student will be involved in recruiting and lab work. They will be able to learn the used techniques under supervision of the tutor. They will actively participate in the daily tasks of a researcher and will actively participate in the lab work, first under supervision and later on independently. They will learn basic lab skills in Liquid chromatography–mass spectrometry (LCMS), High-performance liquid chromatography (HPLC), pyro sequencing, PCR.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
It is an advantage if the student knows some basic lab skills, but this is not obligatory. The student should have a basic understanding of the genome and epigenetic changes. Subjects passed: genetics, biology
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Students in biomedical fields
- Désiron; H.; Donceel; P.; Godderis; L.; Van Hoof; E.; de Rijk; A. (2015). What is the value of occupational therapy in return to work for breast cancer patients? A qualitative inquiry aomong experts. European Journal of Cancer Care; 24 (2); art.nr. doi:10.1111/ecc.12209; 267-280.
- Pauwels; S.; Doperé; I.; Huybrechts; I.; Godderis; L.; Koppen; G.; Vansant; G. (2015). Reproducibility and validity of an FFQ to assess usual intake of methyl-group donors. Public Health Nutrition; 18 (14); 2530-9.
- Vangeel EB; Kempke S; Bakusic J; Godderis L; Luyten P; Van Heddegem L; Compernolle V; Persoons P; Lambrechts D; Izzi B; Freson K; Claes S. Glucocorticoid receptor DNA methylation and childhood trauma in chronic fatigue syndrome patients. J Psychosom Res. 2018 Jan;104:55-60. doi: 10.1016/j.jpsychores.2017.11.011. Epub 2017 Nov 20. PubMed PMID: 29275786.
- Pong; P.; De Munck; J.; Duca; R.; Poels; K.; Covaci; A.; Hoet; P.; Godderis; L.; Van Meerbeek; B.; Van Landuyt; K. (2015). Monomer elution in relation to degree of conversion for different types of composite. Journal of Dentistry; Ahead of print; art.nr. S0300-5712(15)30059- 2.
- Godderis; L.; Schouteden; C.; Tabish; A.; Poels; K.; Hoet; P.; Baccarelli; A.; Van Landuyt; K. (2015). Global Methylation and Hydroxymethylation in DNA from Blood and Saliva in Healthy Volunteers. Global Methylation and Hydroxymethylation in DNA from Blood and Saliva in Healthy Volunteers.; 2015; art.nr. 10.1155/2015/845041; 845041.
- Tabish; A.; Baccarelli; A.; Godderis; L.; Barrow; T.; Hoet; P.; Byun; H. (2015). Assessment of Changes in Global DNA Methylation Levels by Pyrosequencing® of Repetitive Elements. Methods in Molecular Biology; 1315; art.nr. 10.1007/978-1- 4939- 2715-9_15; 201-7.
- Bakusic J; Schaufeli W; Claes S; Godderis L. Stress; burnout and depression: A systematic review on DNA methylation mechanisms. J Psychosom Res. 2017 Jan;92:34-44. doi: 10.1016/j.jpsychores.2016.11.005. Epub 2016 Nov 23. Review. PubMed PMID: 27998510.
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