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Effects of Fucoidan and Proanthocyanidin on Apoptosis in Testicular Tissues of Experimental Diabetic Rats: The Roles of JNK (c-Jun N-terminal kinase), TGF-
Turkey (TurkMSIC) - Trakya University, Edirne
Trakya University School of Medicine, Department of Histology and Embryology
Turan Karaca, PhD, Prof
Assoc. Prof. Gulnur KIZILAY OZFIDAN (PhD), Assist. Prof.Melike SAPMAZ METIN (PhD)
Type of Research Project
- Basic science
What is the background of the project?
The results from studies that focused on inhibitor effcets of fucoidan on MAPKs (Mitogen activated protein kinases) (especially JNK), NFkB (nuclear factor kappaB) and Akt which are playing a role in apoptosis, suggest that fucoidan can be effective on apoptosis in the testis with diabetes mellitus Investigating the JNK inhibitor role of fucoid and JNK phosphorylation decreasing effect of proanthocyanidin are the basis of this study After the diabetic induction via streptozotocin, fucoidan and proanthocyanidin will be administrated in the different time points. At the end of the experiment, testes tissues and blood materials will be harvested and they will be subjected to routine procedures for biochemical, light microscopic, immunohistochemical and western blot analysis. Serum testosterone, tissue superoxide dismutase (SOD), glutathione peroxidase (Gpx) and catalase (CAT) levels will be indicated by biochemically.
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
It is expected that students will develop their bench skills but they should have enthusiasm in biomedical science. There are no legal limitations in the student
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- M.A. 2003.
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