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Pharmacologic Characterization of Leukocyte Trafficking
Austria (AMSA) - University of Graz, Graz
Institute of Experimental and Clinical Pharmacology, Medical University of Graz
Prof. Akos Heinemann, MD
Eva Sturm, Viktoria Konya, Thomas B
Type of Research Project
- Basic science
What is the background of the project?
Leukocyte trafficking from bone marrow to tissue at sites of inflammation is a crucial step in the immune response. Particularly, the interaction of leukocytes with the endothelium is a rate-limiting step herein. Modulation of leukocyte migration and activation through pharmacological agents is an important therapeutic approach to many kinds of inflammatory diseases ranging from allergy to autoimmune diseases. In our lab we are interested particularly in the innate immune system and lung inflammation (asthma, acute lung injury). We mainly use leukocytes that we isolate from human peripheral blood and different cell lines, such as endothelial cells. The aim of the project is to characterize novel targets for pharmacological agents. Flow cytometry, Western blot, qPCR, immunofluorescence microscopy, cell culture
What is the aim of the project?
In our lab we are interested particularly in the innate immune system and lung inflammation (asthma, acute lung injury). We mainly use leukocytes that we isolate from human peripheral blood and different cell lines, such as endothelial cells. The aim of the project is to characterize novel targets for pharmacological agents.
What techniques and methods are used?
Flow cytometry, Western blot, qPCR, immunofluorescence microscopy, cell culture
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Participation in lab work, review of literature, writing of protocols, analysis of data
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Active vaccination against viral hepatitis A and B
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system
- PMID: 26103450; PMID: 24733850; PMID: 23755110; PMID: 23523686
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