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Sphingosine 1-phosphate (S1P) and its receptors in inflammation and sepsis
Germany (bvmd) - Friedrich-Schiller-Universitaet, Jena
Department of Anesthesiology and Intensive Care Medicine, Sepsis Research Group, Center for Molecular Biomedicine (CMB), Hans-Knoell-Str. 2, 07745 Jena, Germany
Prof. Dr. Markus Graeler
Prof. Dr. Markus Graeler
Type of Research Project
- Basic science
What is the background of the project?
S1P is a lipid metabolite and ligand for five different G protein-coupled cell surface receptors designated S1P1-5. S1P signaling is important amongst others for the maintenance of lymphocyte circulation and vascular endothelial barrier integrity, T cell differentiation, and antigen presentation. Due to its central role in these basic vascular and immune functions, S1P most likely also plays a role in the pathology of sepsis, a systemic inflammatory response to infection leading to life-threatening organ dysfunction. This project investigates different aspects of S1P signaling in sepsis.
What is the aim of the project?
The aim of this project is to define the role of S1P signaling in the initiation and progression of sepsis since it seems to have an important role in the inflammation process.
What techniques and methods are used?
Flow cytometry (FACS), liquid chromatography coupled to triple-quadrupole mass spectrometry (LC/MS/MS), fluorescence microscopy, intracellular calcium flux measurements, Western blot, quantitative polymerase chain reaction (qPCR), cell culture, mouse experimentation, enzyme-linked immunosorbent assay (ELISA), biochemical assays.
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The student should be familiar with general lab work. No specific knowledge is required, but some basic understanding of biochemical methods would be beneficial. Importantly, the student should be motivated and eager to learn new methods and concepts and should have some basic interest in the overall topic of lipid signaling, immunity, and sepsis.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Pre-Medical students from the American-British system
- Thuy AV; Reimann CM; Hemdan NY; Graeler MH: Sphingosine 1-phosphate in blood: Function metabolism and fate. Cell Physiol Biochem 2014 34:158-171
- Bode C; Graeler MH: Immune regulation by sphingosine 1-phosphate and its receptors. Arch Immunol Ther Exp (Warsz) 2012
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