Projects
Name
Investigations on Pathogenicity factors of coagulase negative Staphylococci
University
Germany (bvmd) - Ruhr-Universitaet, Bochum
Domain
Microbiology
Departement
Abteilung fuer Medizinische Mikrobiologie, Universitaetsstr. 150, 44801 Bochum, Germany
Head
Prof. Dr. Soeren G. Gatermann
Tutor
Dr. Lennart Marlinghaus (Lennart.Marlinghaus@rub.de)
Languages
English, German
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No No yes yes yes yes No No yes yes yes yes
Type of Research Project
- Basic science
What is the background of the project?
Coagulase negative staphylococci have long been regarded as apathogenic but their important role as pathogens and their increasing incidence have been recognized and studied in recent years. Especially the species Staphylococcus saprophyticus, that causes urinary tract infections and Staphylococcus lugdunensis, which causes endocarditis, osteomyelitis and skin and soft tissue infections are in our scope. Our aim is to analyze pathogenicity factors of the species S. saprophyticus and S. lugdunensis in order to achieve a deeper understanding of the various and serious infections caused by these pathogens. What techniques and methods will be used? Microbiological and molecularbiological methods will be used like PCR (polymerase chain reaction), cloning and construction of mutant pathogens and phenotypic characterization.
What is the aim of the project?
Our aim is to analyze pathogenicity factors of the species S. saprophyticus and S. lugdunensis in order to achieve a deeper understanding of the various and serious infections caused by these pathogens.
What techniques and methods are used?
Microbiological and molecularbiological methods will be used like PCR (polymerase chain reaction), cloning and construction of mutant pathogens and phenotypic characterization.
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Scientific working and writing including basic microbiological techniques and molecularbiological techniques like PCR and molecular cloning.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
1
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Knowledge in the field of microbiology and some kind of lab skills would be preferable, but are not absolutely necessary. A seminar talk (Powerpoint-presentation) and a report that summarizes the outcome of the work is demanded
Are there any legal limitations in the student’s involvement
No
Hours
8
Type of students accepted
This project accepts:
- Medical students
Articles
- FRANK
- K. L.
- DEL POZO
- J. L. & PATEL
- R. 2008. From clinical microbiology to infection pathogenesis: how daring to be different works for Staphylococcus lugdunensis. Clin Microbiol Rev
- 21
- 111-33.
- Kuroda M
- Yamashita A