Projects
Name
Angiogenesis and metabolism in diabetes.
University
Portugal (PorMSIC) - University of Porto, Porto
Domain
Biochemistry
Departement
Department of Biochemistry, Faculty of Medicine, University of Porto
Head
Raquel Soares
Tutor
Raquel Costa, Carolina Silva, Vera Machado
Languages
English, Spanish, Portuguese
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No No No No No No Yes No No No No No
Type of Research Project
- Basic science
What is the background of the project?
Diabetes is increasing worldwide. One of its major complications is the macro and microvascular alterations, which cause high morbidity and mortality rates. Paradoxically, angiogenesis is often both exacerbated and impaired in the same patients. This angiogenic paradox is associated with distinct metabolic pathways occurring in each organ. Therefore, studying the interplay between metabolism and angiogenesis process is of paramount importance to design innovative strategies against diabetic vascular complications.
What is the aim of the project?
Diabetes is increasing worldwide. One of its major complications is the macro and microvascular alterations, which cause high morbidity and mortality rates. Paradoxically, angiogenesis is often both exacerbated and impaired in the same patients. This angiogenic paradox is associated with distinct metabolic pathways occurring in each organ. Therefore, studying the interplay between metabolism and angiogenesis process is of paramount importance to design innovative strategies against diabetic vascular complications.
What techniques and methods are used?
Cell culture assays, animal models, immunohistochemistry, molecular biology, microscopy, TUNEL (apoptosis assay), MTS assay (cell viability), BrdU assay (proliferation), injury assay (cell migration, transwells), matrigel assay (endothelial cell assembly into capillary-like structures)
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
The student will be enrolled in the lab work, and will perform the required assays listed above, always under the supervision of one member of the team.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Some papers from the team will be provided upon arrival
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Short experience concerning working in the lab. MD students from the 3rd, 4th and 5th year are most welcome.
Are there any legal limitations in the student’s involvement
Yes
Hours
6
Type of students accepted
This project accepts:
- Medical students
Articles