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Regulation of adrenergic system in obesity
Portugal (PorMSIC) - University of Porto, Porto
/ Department of Medical Education and Simulation Faculty of Medicine, University of Porto
English, Spanish, Portuguese
Type of Research Project
- Basic science
What is the background of the project?
Several evidences clearly show that the prevalence of obesity is dramatically increasing worldwide, and is associated with an increased risk of cardiovascular disease and metabolic disorders. The updated concept that, besides adrenomedullary, neuron and immune cells, adipocytes also possess a functional adrenergic system, suggest that these cells in response to environmental factors are able to produce and release catecholamines that, in turn, will regulate adipocyte biology through autocrine/paracrine mechanisms.
What is the aim of the project?
Our group aims to further investigate the role of adrenergic system in distinct fat depots under obesity and the intracellular mechanisms involved.
What techniques and methods are used?
Cell culture assays, immunohistochemistry, molecular biology, microscopy, MTT (cell viability) and BrdU assays (proliferation).
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
The student will be enrolled in the lab work, and will perform the required assays listed above, always under the supervision of one member of the team.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Some papers from the team will be provided upon arrival
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Short experience concerning working in the lab. MD students from the 3rd, 4th and 5th year are most welcome.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
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