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Preparation of electro spun Nano fibers for tissue engineering applications and in vitro testing of prepared Nano fibers for tissue regeneration.
Czech Republic (IFMSA CZ) - Charles University, 2nd Medical Faculty, Prague
Biophysics and Medical Physics
Department of Biophysics, 2nd Faculty of Medicine, Charles University,
prof. RNDr. Evzen Amler, CSc.
prof. RNDr. Evzen Amler, CSc.
English, Czech, Slovak
Type of Research Project
- Basic science
What is the background of the project?
Nano fibers formed by electro spinning have been shown to mimic the structure and biological function of the extracellular matrix. Electro spun Nano fibers have a small diameter that closely matches the size scale of the extracellular matrix and the high surface area-to-volume ratio of Nano fibers is ideal for cell attachment, proliferation, differentiation and drug loading. Such unique properties of electro spun Nano fibers make them suitable for various tissue-engineering applications. The aim of the project is to prepare and test properties of prepared scaffold structures for cell growth and differentiation, which will altogether help preparation of damaged tissue (cartilage, bone) What techniques and methods will be used? Technical part : electro-spinning techniques, scanning electron microscopy, laser diffraction, zeta potential In vitro testing : cell culture cultivation techniques (MTS, Pico green assay),confocal microscopy
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic knowledge about Nano fibers, nanotechnologies, tissue engineering andregenerative medicine. Scientific report will be required after the exchange.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system
- RAMPICHOVA; M.; J. CHVOJKA; et al. Elastic three-dimensional poly (e-caprolactone) nanofibre scaffold enhances migration; proliferation and osteogenic differentiation of mesenchymal stem cells. Cell Proliferation. 2013; 46(1): 23-37. DOI: 10.1111/cpr.12001. ISSN 09607722. Available also at: http://doi.wiley.com/10.1111/cpr.12001
- AMLER; Evzen; Andrea MICKOVA a Matej BUZGO. Electrospun core/shell nanofibers: a promising system for cartilage and tissue engineering? Nanomedicine. 2013; 8 (4): 509-512. DOI: 10.2217/nnm.13.19. ISSN 1743-5889. Available also at: http://www.futuremedicine.com/doi/abs/10.2217/nnm.13.19
- PROSECKA; E.; M. RAMPICHOVA; et al. Collagen/hydroxyapatite scaffold enriched with polycaprolactone nanofibers; thrombocyte-rich solution and mesenchymal stem cells promotes regeneration in large bone defect in vivo. Journal of Biomedical Materials Research Part A. 2015; 103(2): 671-682. DOI: 10.1002/jbm.a.35216. ISSN 15493296. Available also at: http://doi.wiley.com/10.1002/jbm.a.35216
- PLENCNER; Martin; Barbora EAST; et al. Abdominal closure reinforcement by using polypropylene mesh functionalized with poly-e-caprolactone nanofibers and growth factors for prevention of incisional hernia formation. International Journal of Nanomedicine. : 3263-. DOI: 10.2147/IJN.S63095. ISSN 1178-2013. Available also at: http://www.dovepress.com/abdominal-closure-reinforcement-by-using-polypropylene-mesh-functional-peer-reviewed-article-IJN
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