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DEFECTIVE NEUTROPHILS CONTRIBUTE TO IMMUNOLOGICAL IMPAIRMENT IN MULTIPLE MYELOMA
Universita degli Studi di Catania
Division of Hematology, AziendaPoliclinico-OVE, University of Catania
Prof. Francesco Di Raimondo
dott. Cesarina Giallongo, dott. Daniele Tibullo, dott. Piera La Cava
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Myeloid Derived Suppressor Cells (G-MDSC) in Multiple Myeloma has been shown. These cells are able to inhibit T-cell activation and function through different mechanisms that include release of arginase (Arg-1) and nitric oxide (NO) in the microenvironment. Due to a large overlapping between G-MDSC and mature granulocytes immunophenotype in humans, we hypothesized that mature neutrophils could be representative of the entire suppressive myeloid population.
What is the aim of the project?
The aim of the project is to investigate if mature neutrophils of patients affected by Multiple Myeloma exhibited differential functional activity compared to neutrophils of MGUS and healthy subjects
What techniques and methods are used?
Tecniques: Flow cytometry, cell cultures,Real-time RT-PCR for gene expression, ELISA
What is the role of the student?
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Students will follow the entire process of the experiments and will be able with time to conduct experiment by him/herself. In addition students could follow the ward and outpatients activity and could be able to integrate information coming from the lab with clinical features of the patients
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
No theoretical teaching provided
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
No special skill is required For further informations: Dasanu CA. Immune alterations in untreated and treated multiple myeloma. J Oncol Pharm Pract 2012; 18: 257-263.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system
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