Development of multifunctional nanodressings
Estonia (EstMSA) - University of Tartu, Tartu
Biotechnologies and Informatics
Department of Pharmacy
Ain Raal
Karin Kogermann, Liis Saks, Ingrid Tamm, I. Laidm
English, Estonian, Finnish
4 weeks
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No No No No Yes Yes No No No No No No
Type of Research Project
- Basic science
What is the background of the project?
Different nanodressings are currently being developed. One example of multifunctional nanodressing is an antimicrobial drug-loaded electrospun nanofibrous matrix which is of major interest as a novel drug delivery system for effective care for chronic wounds. Treatment of wound infection is a crucial part of the therapy and high bioburden leading to persistent infections and systemic toxicity are an increasing antibiotic-related problems. The overall aim of the present project is to design and prepare effective new types of antibacterial nanofibrous dressings (ANDs) for local wound healing purposes using electrospinning (ES) and three dimensional printing. Firstly, the solid-state, mechanical and technological properties of ANDs will be studied. Secondly, the drug release, dissolution and antimicrobial activity and efficiency studies will be performed. Novel methods will be developed for investigating the antibacterial activity of dressings in vitro and in vivo. It is hypothesised that depending on the design and preparation of ANDs, the drug release as well as antimicrobial activity and efficiency will be changed. The main goal of the project is to design and develop novel multicomponent ANDs intended for advanced wound care and investigate their in vitro and in vivo performance. Two important steps in drug development will be investigated: 1) technological AND development (including solid state analysis) and 2) an extensive biopharmaceutical approach revealing the drug release together with the antimicrobial activity. Different analytical techniques will be used for preparation (depending on the availability electrospinning or 3D printing or solvent casting etc) and physicochemical analysis (spectroscopy, X-ray difractometry). In addition, drug release studies and mechanical properties of the matrices will be performed. If possible, also some antibacterial activity studies will be performed. We accept students for different durations (from one month up to 6 months, upon previous agreement)
What is the aim of the project?
Create effective care for chronic wounds with nanotechnology
What techniques and methods are used?
Will be described during the program.
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Will be described during the program.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Some basic laboratory work experience is needed (making solutions, dilutions etc.), all other methods can be learned; motivation to conduct research work is needed and crucial!!!
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts:
- Medical students
- Graduated students (less than 6 months)
- Pre-Medical students from the American-British system