Projects
Name
Molecular processes in the wall of the aortic abdominal aneurysm
University
Poland (IFMSA-Poland) - Medical University of Silesia, Katowice
Domain
Biology
Departement
Department of Molecular Biology and Genetics, Medical University of Silesia in Katowice, Medykow 18 street, 40-752 Katowice, Poland
Head
Prof. Aleksander L. Sieron
Tutor
Prof. Aleksander L. Sieron
Languages
English
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No No No No No No Yes No Yes No No No
Type of Research Project
- Basic science
What is the background of the project?
Aortic abdominal aneurysm is the most common aneurysm of aorta. Research is focused on learning about molecular processes in the aortic wall that may have influence in aneurysm development. The study is based on isolation and culture of cells from abdominal aorta aneurysm. Their fluorescence-activated cell sorting (FACS) analyses, transcription profiling, selected genes sequencing and epigenetic patterning.
What is the aim of the project?
Detection of somatic mutations and role of clonality in non-inherited aneurysm development.
What techniques and methods are used?
Adherent cell isolation and culture, flow cytometry, microarrays, RT PCR, DNA sequencing, methylome patterning, gel electrophoresis.
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Participation and self development.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
1
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Molecular biology, cell biology, histopathology at academic level, pipetting, sample handling, principles of nucleic acids work.
Are there any legal limitations in the student’s involvement
No
Hours
7
Type of students accepted
This project accepts:
- Medical students
- Graduated students (less than 6 months)
- Pre-Medical students from the American-British system
Articles
- Lu S. et all (2013) J. Cardiothoracic surgery. 83
- Lu H. et all (2012) Curr Atheroscler Rep. 14(5): 402-412
- Acosta S. et all J. vasc. Surg. (2006) 44: 237-243
- Ueda K. et all PLOSONE 10(3): .e120689