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Saliva diagnostic as non-invasive laboratory screening method in people with systematic disorders.
Russian Federation (HCCM Russia) - Samara State Medical University, Samara
Department of the Fundamental Biochemistry
Frida N. Gylmiyarova, PhD, Professor
Associate Professor Inna A. Selezneva
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Saliva is a clinically informative, biological fluid (biofluid) that is useful for novel approaches to prognosis, laboratory or clinical diagnosis, and monitoring and management of patients with both oral and systemic diseases. It is easily collected and stored and ideal for early detection of disease as it contains specific soluble biological markers (biomarkers). Saliva contains multiple biomarkers which make it useful for multiplexed assays that are being developed as point-of-care (POC) devices, rapid tests, or in more standardized formats for centralized clinical laboratory operations. Salivary diagnostics is a dynamic field that is being incorporated as part of disease diagnosis, clinical monitoring and for making important clinical decisions for patient care.
What is the aim of the project?
The aim of the project is to discover a new method of fast detecting pathological biomarkers in saliva. To rich this goal we have to perform screening analysis and to compare the results which we have from the group of almost healthy people and people with some specific diseases.
What techniques and methods are used?
• The enzyme-linked immunosorbent assay (ELISA): Immunoglobulin A, Immunoglobulin G, Immunoglobulin M, Interleukin-1, Interleukin-2, Interleukin-4, Interleukin-6, Interleukin-8, tumor necrosis factor (TNF) • Saliva chemistry: pH, Gluose, Amilase, Na, K, P, Mg, Ca • The polymerase chain reaction (PCR)
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
- If the project is clinical
- the student will be allowed to work with patients
What are the tasks expected to be accomplished by the student?
The student will listen to a brief overview of the researches about the saliva diagnostic by their tutor, than they will take part in the study: first as a volunteer (to feel him/herself how it works), than under the supervision of tutors they will be performing the technique of enzyme-linked immunosorbent assay, polymerase chain reaction and saliva chemistry. At the end they will write an article. During the exchange student will master the technique of enzyme-linked immunosorbent assay, polymerase chain reaction and saliva chemistry. As well as he will gain important experience in medical thinking: to find the correlation in medical information, to study medical literature.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Preliminary readings will be provided.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a scientific report - The student will have the opportunity to present the results together with the supervisor at a conference
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Final test or examination in biochemistry should be passed. Student should know the principes of the polimerase chain reaction, the enzyme-linked immunosorbent assay.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
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