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Estrogen receptor gene DNA methylation patterns in idiopathic scoliosis using MSP-PCR.
Poland (IFMSA-Poland) - Poznan University of Medical Sciences, Poznan
Department of Cell Biology
Prof. Malgorzata Kotwicka
Miroslaw Andrusiewicz, PhD
Type of Research Project
- Basic science
What is the background of the project?
Genetic factors are believed to play an important role in the etiology of idiopathic scoliosis (IS). Recent evidence for common diseases suggests epigenetic may be the link between environmental factors and phenotypic differences. DNA methylation is one important epigenetic mechanism operating at the interface between genome and environment to regulate phenotypic plasticity with a complex regulation across the genome during the first decade of life.
What is the aim of the project?
The aim of this study is to explore the relationship of ESR1 and ESR2 DNA methylation with the severity of phenotype and the clinical severity score in idiopathic scoliosis patients.
What techniques and methods are used?
DNA isolation, Bisulfite conversion of DNA, methylation specific PCR.
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Participation and self-development.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic knowledge in molecular biology (particular: nucleic acids replication, transcription and translation), practical and manual skills, ability to work independently and in a team.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system
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