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Regulation of exosome-mediated intercellular communication: its implication in cardiovascular diseases
Portugal (PorMSIC) - University of Coimbra, Coimbra
Neuromodulation group - IBILI
Rodrigo. A. Cunha
English and Portuguese
Type of Research Project
- Basic science
What is the background of the project?
Multicellular organisms rely on highly regulated mechanisms to ensure a correct and efficient communication between the various cells that form the organs and tissues. The intercellular communication can be direct, through gap junction channels formed between adjacent cells, or indirectly, at long distances, via extracellular vesicles, that convey the biological information between the producing and the acceptor cells. In our lab we are particularly interested in a specific type of intercellular communication that involves extracellular vesicles called exosomes, and how it can be implicated in cardiovascular diseases.
What is the aim of the project?
In this project we aim to demonstrate that Cx43, the main constituent of gap junctions, can also regulate the communication between cells and exosomes.
What techniques and methods are used?
This project will make use of several cellular and molecular biology techniques including: Mutation of plasmid DNA, cell culture and transfection, immunoprecipitation, western blot, immunofluorescence and electron transmission microscopy.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks of the student will be performed on his/her own
What are the tasks expected to be accomplished by the student?
The student is expected to learn some of the techniques employed in our lab and carry out some basic experiments, independently.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Students will be provided with scientific articles giving a background of the project as well as a lecture explaining the aims and the methodology being employed in the project.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic concepts about Neuroscience and laboratory practice. There are no legal limitations for the student
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
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